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PPP1R16A protein phosphatase 1 regulatory subunit 16A [ Homo sapiens (human) ]

Gene ID: 84988, updated on 5-Mar-2024

Summary

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Official Symbol
PPP1R16Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 16Aprovided by HGNC
Primary source
HGNC:HGNC:14941
See related
Ensembl:ENSG00000160972 MIM:609172; AllianceGenome:HGNC:14941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYPT3
Summary
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]
Expression
Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144477982..144502121)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145647722..145671886)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145703365..145727504)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TMEM276-ZFTRAF1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145689275-145689888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145692087-145692923 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145698787-145699682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145699683-145700576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145701473-145702366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19696 Neighboring gene forkhead box H1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145709653-145710352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145710353-145711052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145715271-145715770 Neighboring gene uncharacterized LOC101928953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145725199-145725860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19697 Neighboring gene Sharpr-MPRA regulatory region 2015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145729171-145729831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145735245-145735868 Neighboring gene glutamic--pyruvic transaminase Neighboring gene major facilitator superfamily domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood. Burkhardt R, et al. PLoS Genet, 2015 Sep. PMID 26401656, Free PMC Article
  2. Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity. Ruan Y, et al. J Biol Chem, 2011 Aug 19. PMID 21712390, Free PMC Article
  3. Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A. Yong J, et al. J Biol Chem, 2006 Oct 20. PMID 16920702
  4. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Skinner JA, et al. Biochem J, 2001 May 15. PMID 11336659, Free PMC Article
  5. Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma. Igci YZ, et al. Endocr Pathol, 2011 Jun. PMID 21509594

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPP1R16A gene expression is decreased in follicular variant of papillary thyroid carcinoma.
    Title: Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
  2. analysis of a novel mechanism for the phosphorylation of MYPT3 by PKA and activation of the catalytic activity through direct interaction of a central region of MYPT3 with its N-terminal region
    Title: Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14333

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 16A
Names
myosin phosphatase-targeting subunit 3
protein phosphatase 1, regulatory (inhibitor) subunit 16A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329442.2 → NP_001316371.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC084125, BC053506, DB457525, HY013777, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75 → 101
    ANK; ANK repeat [structural motif]

  2. NM_001329443.2 → NP_001316372.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, CN301973, DB457525, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34
    Related
    ENSP00000391126.1, ENST00000435887.2
    Conserved Domains (3) summary
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75 → 101
    ANK; ANK repeat [structural motif]

  3. NM_001329444.2 → NP_001316373.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, BM761618, HY168641, HY176205
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75 → 101
    ANK; ANK repeat [structural motif]

  4. NM_001329445.2 → NP_001316374.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, BM762557, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75 → 101
    ANK; ANK repeat [structural motif]

  5. NM_032902.7 → NP_116291.1  protein phosphatase 1 regulatory subunit 16A

    See identical proteins and their annotated locations for NP_116291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC084125, BC053506, DB457525, HY050499, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75 → 101
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144477982..144502121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422334.1 → XP_047278290.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  2. XM_047422350.1 → XP_047278306.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  3. XM_047422335.1 → XP_047278291.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  4. XM_047422341.1 → XP_047278297.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  5. XM_047422351.1 → XP_047278307.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  6. XM_047422331.1 → XP_047278287.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  7. XM_047422340.1 → XP_047278296.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  8. XM_047422347.1 → XP_047278303.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  9. XM_047422337.1 → XP_047278293.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  10. XM_047422345.1 → XP_047278301.1  protein phosphatase 1 regulatory subunit 16A isoform X3

    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34

  11. XM_047422336.1 → XP_047278292.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  12. XM_047422342.1 → XP_047278298.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  13. XM_047422349.1 → XP_047278305.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  14. XM_047422338.1 → XP_047278294.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  15. XM_047422343.1 → XP_047278299.1  protein phosphatase 1 regulatory subunit 16A isoform X3

    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34

  16. XM_047422332.1 → XP_047278288.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  17. XM_047422348.1 → XP_047278304.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  18. XM_047422339.1 → XP_047278295.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  19. XM_047422346.1 → XP_047278302.1  protein phosphatase 1 regulatory subunit 16A isoform X3

    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34

  20. XM_047422352.1 → XP_047278308.1  protein phosphatase 1 regulatory subunit 16A isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145647722..145671886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361386.1 → XP_054217361.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  2. XM_054361399.1 → XP_054217374.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  3. XM_054361387.1 → XP_054217362.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  4. XM_054361392.1 → XP_054217367.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  5. XM_054361400.1 → XP_054217375.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  6. XM_054361384.1 → XP_054217359.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  7. XM_054361391.1 → XP_054217366.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  8. XM_054361396.1 → XP_054217371.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  9. XM_054361389.1 → XP_054217364.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  10. XM_054361395.1 → XP_054217370.1  protein phosphatase 1 regulatory subunit 16A isoform X3

    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34

  11. XM_054361388.1 → XP_054217363.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  12. XM_054361393.1 → XP_054217368.1  protein phosphatase 1 regulatory subunit 16A isoform X2

  13. XM_054361398.1 → XP_054217373.1  protein phosphatase 1 regulatory subunit 16A isoform X4

  14. XM_054361390.1 → XP_054217365.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  15. XM_054361394.1 → XP_054217369.1  protein phosphatase 1 regulatory subunit 16A isoform X3

    UniProtKB/Swiss-Prot
    D3DWM5, Q96I34

  16. XM_054361385.1 → XP_054217360.1  protein phosphatase 1 regulatory subunit 16A isoform X1

  17. XM_054361397.1 → XP_054217372.1  protein phosphatase 1 regulatory subunit 16A isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96I34.1 GenPept UniProtKB/Swiss-Prot:Q96I34

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