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RRT12 Rrt12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850412, updated on 13-Apr-2024

Summary

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Gene symbol
RRT12
Gene description
Rrt12p
Primary source
SGD:S000000641
Locus tag
YCR045C
See related
AllianceGenome:SGD:S000000641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OSW3
Summary
Predicted to enable serine-type endopeptidase activity. Involved in ascospore wall assembly. Located in ascospore wall and nuclear envelope. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (208135..209610, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Per1p Neighboring gene mitochondrial 54S ribosomal protein IMG1 Neighboring gene 18S rRNA (guanine1575-N7)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ascospore wall IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spore wall IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rrt12p
NP_009974.1
  • Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    208135..209610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178759.1 → NP_009974.1  TPA: Rrt12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009974.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR54, P25381
    UniProtKB/TrEMBL
    A0A8H4F7P3, B3LUB0, B5VEY6, C7GJU0, C8Z4D5, N1P7N6
    Conserved Domains (1) summary
    cd04077
    Location:130 → 398
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25381.1

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