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ASP3-3 asparaginase ASP3-3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850855, updated on 13-Apr-2024

Summary

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Gene symbol
ASP3-3
Gene description
asparaginase ASP3-3
Primary source
SGD:S000004148
Locus tag
YLR158C
See related
AllianceGenome:SGD:S000004148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ASP3
Summary
Enables asparaginase activity. Involved in asparagine catabolic process and cellular response to nitrogen starvation. Located in cell wall-bounded periplasmic space. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ASP3-3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (482549..483637, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae asparaginase II, a potential antileukemic drug: Purification and characterization of the enzyme expressed in Pichia pastoris. Facchinetti de Castro Girão L, et al. Protein Expr Purif, 2016 Apr. PMID 26714301
  2. The ASP3 locus in Saccharomyces cerevisiae originated by horizontal gene transfer from Wickerhamomyces. League GP, et al. FEMS Yeast Res, 2012 Nov. PMID 22776361
  3. Asparaginase II of Saccharomyces cerevisiae. GLN3/URE2 regulation of a periplasmic enzyme. Bon EP, et al. Appl Biochem Biotechnol, 1997 Spring. PMID 9170245
  4. Asparaginase II of Saccharomyces cerevisiae: positive selection of two mutations that prevent enzyme synthesis. Kim KW, et al. J Bacteriol, 1984 Mar. PMID 6365897, Free PMC Article
  5. Asparaginase II of Saccharomyces cerevisiae: comparison of enzyme stability in vivo and in vitro. Kim KW, et al. Biochemistry, 1983 May 24. PMID 6347251

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparaginase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparaginase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparagine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in asparagine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in asparagine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nitrogen starvation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell wall-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
asparaginase ASP3-3
NP_013259.1
  • Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    482549..483637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182045.1 → NP_013259.1  TPA: asparaginase ASP3-3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013259.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYF3, P0CX77, P0CX78, P0CX79, P0CZ17, P11163, Q12268, Q6Q5K8, Q6Q5K9
    UniProtKB/TrEMBL
    C7GW79, I9KWS0
    Conserved Domains (1) summary
    TIGR00520
    Location:9 → 359
    asnASE_II; L-asparaginase, type II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX77.1
P0CX78.1
P0CX79.1
P0CZ17.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials