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DBP9 ATP-dependent DNA/RNA helicase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850982, updated on 17-May-2024

Summary

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Gene symbol
DBP9
Gene description
ATP-dependent DNA/RNA helicase
Primary source
FungiDB:YLR276C
Locus tag
YLR276C
See related
SGD:S000004266; AllianceGenome:SGD:S000004266; VEuPathDB:YLR276C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA helicase activity; DNA/RNA helicase activity; and RNA helicase activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human DDX56 (DEAD-box helicase 56). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DBP9 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (695046..696830, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene MCM DNA helicase complex subunit MCM5 Neighboring gene mRNA splicing protein SMD2 Neighboring gene cleavage polyadenylation factor subunit YSH1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dbp9p, a member of the DEAD box protein family, exhibits DNA helicase activity. Kikuma T, et al. J Biol Chem, 2004 May 14. PMID 15028736
  2. Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p. Daugeron MC, et al. RNA, 2001 Sep. PMID 11565753, Free PMC Article
  3. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis. Rosado IV, et al. Mol Cell Biol, 2007 Feb. PMID 17145778, Free PMC Article
  4. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article
  5. Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis. Bernstein KA, et al. Mol Cell Biol, 2006 Feb. PMID 16449635, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent DNA/RNA helicase
NP_013378.1
  • DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    695046..696830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182163.1 → NP_013378.1  TPA: ATP-dependent DNA/RNA helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013378.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A1G0, D6VYS3, Q06218, Q66R46
    UniProtKB/TrEMBL
    A0A6A5PTJ2, B3RHF8, B5VNI7, C7GVT4, C8ZDP0, G2WJA2, N1NZJ2
    Conserved Domains (1) summary
    COG0513
    Location:16 → 589
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06218.1

Gene LinkOut

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