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UBC12 NEDD8-conjugating protein UBC12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851015, updated on 4-Aug-2021

Summary

Gene symbol
UBC12
Gene description
NEDD8-conjugating protein UBC12
Primary source
SGD:S000004297
Locus tag
YLR306W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See UBC12 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (744151..744851)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene aconitate hydratase ACO1 Neighboring gene 1-phosphatidylinositol 4-kinase STT4 Neighboring gene chitin deacetylase CDA1 Neighboring gene Dpa10p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the UBC12 gene: The UBC12 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NEDD8 transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NEDD8 transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NEDD8-conjugating protein UBC12
NP_013409.1
  • Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    744151..744851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182194.1NP_013409.1  TPA: NEDD8-conjugating protein UBC12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52491
    Conserved Domains (1) summary
    COG5078
    Location:26178
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
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