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FBP1 fructose 1,6-bisphosphate 1-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851092, updated on 13-Apr-2024

Summary

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Gene symbol
FBP1
Gene description
fructose 1,6-bisphosphate 1-phosphatase
Primary source
SGD:S000004369
Locus tag
YLR377C
See related
AllianceGenome:SGD:S000004369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACN8
Summary
Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis and reactive oxygen species metabolic process. Located in cytosol and periplasmic space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (873746..874792, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Stp3p Neighboring gene Psy3p Neighboring gene tRNA-Lys Neighboring gene translocon subunit SEC61

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex. Ben-Nissan G, et al. Anal Chem, 2017 Apr 18. PMID 28345864, Free PMC Article
  2. The sequence spectrum of frameshift reversions obtained with a novel adaptive mutation assay in Saccharomyces cerevisiae. Heidenreich E, et al. Data Brief, 2016 Dec. PMID 27924298, Free PMC Article
  3. Glucose starvation as a selective tool for the study of adaptive mutations in Saccharomyces cerevisiae. Heidenreich E, et al. J Microbiol Methods, 2017 Jan. PMID 27838539
  4. cpFBPaseII, a novel redox-independent chloroplastic isoform of fructose-1,6-bisphosphatase. Serrato AJ, et al. Plant Cell Environ, 2009 Jul. PMID 19220782
  5. Elements from the cAMP signaling pathway are involved in the control of expression of the yeast gluconeogenic gene FBP1. Zaragoza O, et al. FEBS Lett, 2001 Oct 12. PMID 11602258

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
    Title: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
  2. Hypothesized that decreased FBP1 mRNA level could be due to the effect of Maf1 on tgm silencing (tRNA gene mediated silencing).
    Title: Maf1, repressor of tRNA transcription, is involved in the control of gluconeogenetic genes in Saccharomyces cerevisiae.
  3. Cdc48(Ufd1-Npl4) complex and the ubiquitin receptors Dsk2 and Rad23 act between between polyubiquitination of FBPase and its degradation by the proteasome.
    Title: The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase.
  4. fructose-1,6-bisphosphatase and malate dehydrogenase degradation is mediated by distinct proteolytic pathways and signaling events
    Title: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events.
  5. Influences the connection between DNA damage, aging and oxidative stress through either direct signalling or an intricate adaptation in energy metabolism.
    Title: Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose 1,6-bisphosphate 1-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sucrose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fructose 1,6-bisphosphate 1-phosphatase
NP_013481.3
  • Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    873746..874792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182266.3 → NP_013481.3  TPA: fructose 1,6-bisphosphate 1-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013481.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ13, P09201
    UniProtKB/TrEMBL
    A0A6A5PV82, A7A1Q3, B5VNR4, C7GRW9, C8ZDY7, G2WJJ3, N1P043
    Conserved Domains (1) summary
    COG0158
    Location:20 → 348
    Fbp; Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09201.2

Gene LinkOut

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