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carB carbamoyl-phosphate synthase large subunit [ Methanocaldococcus vulcanius M7 ]

Gene ID: 8513688, updated on 15-Apr-2023

Summary

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Gene symbol
carB
Gene description
carbamoyl-phosphate synthase large subunit
Locus tag
METVU_RS06610
Gene type
protein coding
Organism
Methanocaldococcus vulcanius M7 (strain: M7, culture-collection: ATCC:700851, type-material: type strain of Methanocaldococcus vulcanius)
Lineage
Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus
Old locus tag
Metvu_1345
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Genomic context

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Sequence:
NC_013407.1 (1345108..1346964, complement)

NC_013407.1Genomic Context describing neighboring genes Neighboring gene KEOPS complex subunit Pcc1 Neighboring gene methionine adenosyltransferase Neighboring gene DUF86 domain-containing protein Neighboring gene nucleotidyltransferase family protein Neighboring gene DUF2283 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_013407.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid. Khedouri E, et al. Biochemistry, 1966 Nov. PMID 5339592
  2. Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits. Trotta PP, et al. J Biol Chem, 1974 Jan 25. PMID 4358555
  3. Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. Miles BW, et al. J Biol Chem, 2002 Feb 8. PMID 11729189
  4. Long-range allosteric transitions in carbamoyl phosphate synthetase. Thoden JB, et al. Protein Sci, 2004 Sep. PMID 15322282, Free PMC Article
  5. The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Thoden JB, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jan. PMID 10089390

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
carbamoyl-phosphate synthase large subunit
WP_015733417.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_013407.1 Reference assembly

    Range
    1345108..1346964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_015733417.1 carbamoyl-phosphate synthase large subunit [Methanocaldococcus vulcanius]

    See identical proteins and their annotated locations for WP_015733417.1

    UniProtKB/TrEMBL
    C9RHZ6
    Conserved Domains (4) summary
    COG0458
    Location:90 → 470
    CarB; Carbamoylphosphate synthase large subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]
    cd01424
    Location:482 → 592
    MGS_CPS_II; Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways ...
    pfam02787
    Location:7 → 68
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:203 → 404
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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