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ITR1 myo-inositol transporter ITR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852108, updated on 3-Mar-2024

Summary

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Gene symbol
ITR1
Gene description
myo-inositol transporter ITR1
Primary source
SGD:S000002905
Locus tag
YDR497C
See related
AllianceGenome:SGD:S000002905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport; pseudohyphal growth; and transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ITR1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1443713..1445467, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene CORVET complex subunit VPS3 Neighboring gene Puf6p Neighboring gene Sec20p Neighboring gene Lcd1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of the inositol transporter Itr1p by hydrogen peroxide in Saccharomyces cerevisiae. Santos T, et al. Arch Microbiol, 2019 Jan. PMID 30283989
  2. Regulation of inositol transport in Saccharomyces cerevisiae involves inositol-induced changes in permease stability and endocytic degradation in the vacuole. Lai K, et al. J Biol Chem, 1995 Feb 10. PMID 7852314
  3. Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput. Almeida LD, et al. mBio, 2021 Dec 21. PMID 34903049, Free PMC Article
  4. Two major inositol transporters and their role in cryptococcal virulence. Wang Y, et al. Eukaryot Cell, 2011 May. PMID 21398509, Free PMC Article
  5. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Xue C, et al. mBio, 2010 May 18. PMID 20689743, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
    Title: Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables myo-inositol transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables myo-inositol:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in myo-inositol import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myo-inositol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in myo-inositol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyol transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myo-inositol transporter ITR1
NP_010785.1
  • Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1443713..1445467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180805.1 → NP_010785.1  TPA: myo-inositol transporter ITR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010785.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTB9, P30605
    UniProtKB/TrEMBL
    A0A6A5Q4H8, A6ZZ86, B3LFH0, C7GKT4, G2WBM5, N1P919
    Conserved Domains (1) summary
    cd17360
    Location:92 → 533
    MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30605.2

Gene LinkOut

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