SMT3 SUMO family protein SMT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: SMT3
Gene description: SUMO family protein SMT3
Primary source: SGD:S000002918
Locus tag: YDR510W
See related: AllianceGenome:SGD:S000002918
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein tag. Involved in protein sumoylation. Located in condensed nuclear chromosome and septin ring. Used to study cancer. Human ortholog(s) of this gene implicated in orofacial cleft 10 and type 1 diabetes mellitus 5. Orthologous to several human genes including SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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the library of Smt3 mutants represents a valuable resource for further exploring the functions of sumoylation in cellular stress response and other SUMO-dependent pathways.
Title: A high throughput mutagenic analysis of yeast sumo structure and function.
Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends
Title: In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.
Cdk1 and SUMO (Smt3) regulate Swe1 stability
Title: Cdk1 and SUMO regulate Swe1 stability.
the Zn(2+) motif of E1 has a role in SUMO adenylation
Title: Role of the Zn(2+) motif of E1 in SUMO adenylation.
A model is proposed for the positive control of the centromeric pool of Top2p, required for high minichromosome segregation fidelity, by Smt3p modification.
Title: SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by the sumoylation of topoisomerase II.
there are a broad array of cellular processes regulated by SUMO conjugation
Title: Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae.
analysis of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p
Title: Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a non-covalent ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tag activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in septin ring	IDA Inferred from Direct Assay more info	PubMed

NP_010798.1

Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant

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