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COQ1 trans-hexaprenyltranstransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852288, updated on 2-May-2024

Summary

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Gene symbol
COQ1
Gene description
trans-hexaprenyltranstransferase
Primary source
SGD:S000000207
Locus tag
YBR003W
See related
AllianceGenome:SGD:S000000207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables trans-hexaprenyltranstransferase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Orthologous to human PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (242809..244230)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene alpha,alpha-trehalase NTH2 Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene GPI-anchor transamidase GPI18 Neighboring gene Rcr1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. Ohara K, et al. J Exp Bot, 2010 Jun. PMID 20421194, Free PMC Article
  2. Biological significance of the side chain length of ubiquinone in Saccharomyces cerevisiae. Okada K, et al. FEBS Lett, 1998 Jul 17. PMID 9708911
  3. Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone. Okada K, et al. Biochim Biophys Acta, 1996 Aug 16. PMID 8765142
  4. Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. Ashby MN, et al. J Biol Chem, 1990 Aug 5. PMID 2198286
  5. Overproduction of isoprenoids by Saccharomyces cerevisiae in a synthetic grape juice medium in the absence of plant genes. Camesasca L, et al. Int J Food Microbiol, 2018 Oct 3. PMID 29902782

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The product distribution in the strains indicated that the energy barrier could be the reason that different metal ion-assisted electrophilic attacks initiated carbocation formation.
    Title: ERG9 and COQ1 disruption reveals isoprenoids biosynthesis is closely related to mitochondrial function in Saccharomyces cerevisiae.
  2. Coq1 is functional when expressed alone in E. coli and in budding yeast, but is only functional as a partner with Dps1 in fission yeast.
    Title: Heteromer formation of a long-chain prenyl diphosphate synthase from fission yeast Dps1 and budding yeast Coq1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heptaprenyl diphosphate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trans-hexaprenyltranstransferase
NP_009557.1
  • Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    242809..244230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178351.1 → NP_009557.1  TPA: trans-hexaprenyltranstransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ04, P18900
    UniProtKB/TrEMBL
    A0A8H4BT98, A6ZKV0, B3LND7, C7GM46, C8Z3Z9, G2W911
    Conserved Domains (1) summary
    cl00210
    Location:48 → 471
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18900.1

Gene LinkOut

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