Cnga3 cyclic nucleotide gated channel subunit alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnga3provided by RGD
Official Full Name: cyclic nucleotide gated channel subunit alpha 3provided by RGD
Primary source: RGD:70948
See related: Ensembl:ENSRNOG00000051950 AllianceGenome:RGD:70948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CNGgust
Summary: Enables cGMP binding activity; intracellular cGMP-activated cation channel activity; and protein C-terminus binding activity. Involved in several processes, including inorganic cation import across plasma membrane; response to cAMP; and response to magnesium ion. Located in several cellular components, including axon initial segment; glial cell projection; and perikaryon. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 14.3) and Testes (RPKM 5.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (46943353..46989862)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (39447534..39494044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (43807412..43858225)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that CNGA3 interacts with cadherin 23 and with cadherin 23 binding partner, myosin VIIa.
Title: Cyclic nucleotide-gated channel α-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction.
Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 intracellular sequence that follows a predicted transmembrane domain in the C-terminus
Title: CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.
This study showed that widespread expression of the CNGA3 in the rat olfactory bulb. appears in principal cells, including mitral cells and internal, medium and external tufted cells.
Title: Distribution of the A3 subunit of the cyclic nucleotide-gated ion channels in the main olfactory bulb of the rat.
Renal CNG-A3 mRNA and protein expression were lowered by high Na+ diet; aldosterone modulation was present in the cortical thick ascending loop and cortical collecting duct. Results suggests CNG-A3 may have a physiological role in sodium reabsorption.
Title: Modulation of renal CNG-A3 sodium channel in rats subjected to low- and high-sodium diets.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	NAS Non-traceable Author Statement more info	PubMed
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	NAS Non-traceable Author Statement more info	PubMed
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in inorganic cation import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal cone cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in cone photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of transmembrane transporter complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclic nucleotide-gated cation channel alpha-3

Names: cyclic nucleotide gated channel alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398686.1 → NP_001385615.1 cyclic nucleotide-gated cation channel alpha-3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0G2KB16, Q9ER33

Related

ENSRNOP00000075614.1, ENSRNOT00000081651.2

Conserved Domains (3) summary

cd00038
Location:462 → 578

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:148 → 390

Ion_trans; Ion transport protein

pfam16526
Location:578 → 647

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
NM_001398687.1 → NP_001385616.1 cyclic nucleotide-gated cation channel alpha-3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0G2K8A7, Q9ER32

Related

ENSRNOP00000074533.1, ENSRNOT00000081250.2

Conserved Domains (3) summary

cd00038
Location:424 → 540

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:110 → 352

Ion_trans; Ion transport protein

pfam16526
Location:540 → 609

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels