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MAL32 alpha-glucosidase MAL32 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852602, updated on 11-Apr-2024

Summary

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Gene symbol
MAL32
Gene description
alpha-glucosidase MAL32
Primary source
SGD:S000000503
Locus tag
YBR299W
See related
AllianceGenome:SGD:S000000503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glucan 1,4-alpha-maltotriohydrolase activity; maltose alpha-glucosidase activity; and sucrose alpha-glucosidase activity. Involved in maltose catabolic process and sucrose catabolic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to several human genes including SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MAL32 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (805351..807105)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene maltose permease Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU24 Neighboring gene Cos2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Attachment of MAL32-encoded maltase on the outside of yeast cells improves maltotriose utilization. Dietvorst J, et al. Yeast, 2007 Jan. PMID 17192852
  2. Effect of Ca(2+) on the activity and structure of α-glucosidase: inhibition kinetics and molecular dynamics simulations. Zhang X, et al. J Biosci Bioeng, 2014 Jun. PMID 24457149
  3. Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication. Voordeckers K, et al. PLoS Biol, 2012. PMID 23239941, Free PMC Article
  4. Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. Ingavat N, et al. J Nat Prod, 2009 Nov. PMID 19824618
  5. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Lee DS, et al. Int J Mol Med, 2007 Sep. PMID 17671744

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Only one phenolic -OH group was alpha-anomer-selectively glucosylated by alpha-glucosidase.
    Title: Synthesis of hydroquinone-alpha-glucoside by alpha-glucosidase from baker's yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucan 1,4-alpha-maltotriohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucan 1,4-alpha-maltotriohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables maltose alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables maltose alpha-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables maltose alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oligo-1,6-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose alpha-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in disaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in maltose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maltose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maltose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sucrose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sucrose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
alpha-glucosidase MAL32
NP_009858.3
  • Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    805351..807105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178647.3 → NP_009858.3  TPA: alpha-glucosidase MAL32 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009858.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQU5, P38158
    UniProtKB/TrEMBL
    A0A8H4F6L2, A6ZLN9, A6ZUU5, B3LML3, B5VEP2, C7GT48, F8LG06, G2WF18, N1PAX0
    Conserved Domains (2) summary
    cd11333
    Location:15 → 501
    AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
    pfam16657
    Location:511 → 583
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38158.1

Gene LinkOut

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