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Bmp7 bone morphogenetic protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85272, updated on 12-Jan-2022

Summary

Official Symbol
Bmp7provided by RGD
Official Full Name
bone morphogenetic protein 7provided by RGD
Primary source
RGD:620743
See related
Ensembl:ENSRNOG00000053384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BMP-7
Summary
Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 205.4), Thymus (RPKM 29.5) and 6 other tissues See more
Orthologs
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Genomic context

See Bmp7 in Genome Data Viewer
Location:
3q42
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161639915..161716938, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170879972..170955820, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101815 Neighboring gene uncharacterized LOC102550368 Neighboring gene SPO11, initiator of meiotic double stranded breaks Neighboring gene ribonucleic acid export 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in allantois development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chorio-allantoic fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in eye development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hindbrain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchyme development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesonephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephric mesenchyme morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of prostatic bud formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in nephrogenic mesenchyme morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neural fold elevation formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein 7
Names
bone moorphogenic protein-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191856.3NP_001178785.1  bone morphogenetic protein 7 precursor

    See identical proteins and their annotated locations for NP_001178785.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000120
    UniProtKB/TrEMBL
    G3V6W8
    Related
    ENSRNOP00000070891.1, ENSRNOT00000084990.2
    Conserved Domains (2) summary
    cd19397
    Location:324430
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
    pfam00688
    Location:35279
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    161639915..161716938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106002.1XP_038961930.1  bone morphogenetic protein 7 isoform X1

    Related
    ENSRNOP00000087993.1, ENSRNOT00000101894.1
    Conserved Domains (2) summary
    cd19397
    Location:258364
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
    pfam00688
    Location:35252
    TGFb_propeptide; TGF-beta propeptide
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