SCL1 proteasome core particle subunit alpha 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852873, updated on 13-Apr-2024

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Summary

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Gene symbol: SCL1
Gene description: proteasome core particle subunit alpha 1
Primary source: SGD:S000002979
Locus tag: YGL011C
See related: AllianceGenome:SGD:S000002979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PRC2
Summary: Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in mitochondrion. Part of proteasome core complex, alpha-subunit complex. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (474489..475247, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome core particle subunit alpha 1

NP_011504.3

Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

474489..475247 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180876.3 → NP_011504.3 TPA: proteasome core particle subunit alpha 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011504.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUC6, P15708, P21243

UniProtKB/TrEMBL

A0A6A5PYC9, A6ZUY2, B3LIM6, B5VIV2, C7GK62, C8Z8N2, G2WE82, N1P3C8

Conserved Domains (1) summary

cd03754
Location:12 → 228

proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3JCO_A.1
3JCO_a.1
3JCP_A.1
3JCP_a.1
3UN4_G.1
3UN4_U.1
3UN8_G.1
3UN8_U.1
3WXR_A.1
3WXR_O.1
4G4S_A.1
4JSQ_G.1
4JSQ_U.1
4JSU_G.1
4JSU_U.1
4JT0_G.1
4JT0_U.1
4LTC_G.1
4LTC_U.1
4NNN_G.1
4NNN_U.1
4NNW_G.1
4NNW_U.1
4NO1_G.1
4NO1_U.1
4NO6_G.1
4NO6_U.1
4NO8_G.1
4NO8_U.1
4NO9_G.1
4NO9_U.1
4Q1S_G.1
4Q1S_U.1
4QBY_G.1
4QBY_U.1
4QLQ_G.1
4QLQ_U.1
4QLS_G.1
4QLS_U.1
4QLT_G.1
4QLT_U.1
4QLU_G.1
4QLU_U.1
4QLV_G.1
4QLV_U.1
4QUX_G.1
4QUX_U.1
4QUY_G.1
4QUY_U.1
4QV0_G.1
4QV0_U.1
4QV1_G.1
4QV1_U.1
4QV3_G.1
4QV3_U.1
4QV4_G.1
4QV4_U.1
4QV5_G.1
4QV5_U.1
4QV6_G.1
4QV6_U.1
4QV7_G.1
4QV7_U.1
4QV8_G.1
4QV8_U.1
4QV9_G.1
4QV9_U.1
4QVL_G.1
4QVL_U.1
4QVM_G.1
4QVM_U.1
4QVN_G.1
4QVN_U.1
4QVP_G.1
4QVP_U.1
4QVQ_G.1
4QVQ_U.1
4QVV_G.1
4QVV_U.1
4QVW_G.1
4QVW_U.1
4QVY_G.1
4QVY_U.1
4QW0_G.1
4QW0_U.1
4QW1_G.1
4QW1_U.1
4QW3_G.1
4QW3_U.1
4QW4_G.1
4QW4_U.1
4QW5_G.1
4QW5_U.1
4QW6_G.1
4QW6_U.1
4QW7_G.1
4QW7_U.1
4QWF_G.1
4QWF_U.1
4QWG_G.1
4QWG_U.1
4QWI_G.1
4QWI_U.1
4QWJ_G.1
4QWJ_U.1
4QWK_G.1
4QWK_U.1
4QWL_G.1
4QWL_U.1
4QWR_G.1
4QWR_U.1
4QWS_G.1
4QWS_U.1
4QWU_G.1
4QWU_U.1
4QWX_G.1
4QWX_U.1
4QXJ_G.1
4QXJ_U.1
4QZ0_G.1
4QZ0_U.1
4QZ1_G.1
4QZ1_U.1
4QZ2_G.1
4QZ2_U.1
4QZ3_G.1
4QZ3_U.1
4QZ4_G.1
4QZ4_U.1
4QZ5_G.1
4QZ5_U.1
4QZ6_G.1
4QZ6_U.1
4QZ7_G.1
4QZ7_U.1
4QZW_G.1
4QZW_U.1
4QZX_G.1
4QZX_U.1
4QZZ_G.1
4QZZ_U.1
4R00_G.1
4R00_U.1
4R02_G.1
4R02_U.1
4R17_G.1
4R17_U.1
4R18_G.1
4R18_U.1
4RUR_G.1
4RUR_U.1
4X6Z_A.1
4X6Z_O.1
4Y69_G.1
4Y69_U.1
4Y6A_G.1
4Y6A_U.1
4Y6V_G.1
4Y6V_U.1
4Y6Z_G.1
4Y6Z_U.1
4Y70_G.1
4Y70_U.1
4Y74_G.1
4Y74_U.1
4Y75_G.1
4Y75_U.1
4Y77_G.1
4Y77_U.1
4Y78_G.1
4Y78_U.1
4Y7W_G.1
4Y7W_U.1
4Y7X_G.1
4Y7X_U.1
4Y7Y_G.1
4Y7Y_U.1
4Y80_G.1
4Y80_U.1
4Y81_G.1
4Y81_U.1
4Y82_G.1
4Y82_U.1
4Y84_G.1
4Y84_U.1
4Y8G_G.1
4Y8G_U.1
4Y8H_G.1
4Y8H_U.1
4Y8I_G.1
4Y8I_U.1
4Y8J_G.1
4Y8J_U.1
4Y8K_G.1
4Y8K_U.1
4Y8L_G.1
4Y8L_U.1
4Y8M_G.1
4Y8M_U.1
4Y8N_G.1
4Y8N_U.1
4Y8O_G.1
4Y8O_U.1
4Y8P_G.1
4Y8P_U.1
4Y8Q_G.1
4Y8Q_U.1
4Y8R_G.1
4Y8R_U.1
4Y8S_G.1
4Y8S_U.1
4Y8T_G.1
4Y8T_U.1
4Y8U_G.1
4Y8U_U.1
4Y9Y_G.1
4Y9Y_U.1
4Y9Z_G.1
4Y9Z_U.1
4YA0_G.1
4YA0_U.1
4YA1_G.1
4YA1_U.1
4YA2_G.1
4YA2_U.1
4YA3_G.1
4YA3_U.1
4YA4_G.1
4YA4_U.1
4YA5_G.1
4YA5_U.1
4YA7_G.1
4YA7_U.1
4YA9_G.1
4YA9_U.1
4Z1L_G.1
4Z1L_U.1
5BOU_G.1
5BOU_U.1
5BXL_G.1
5BXL_U.1
5BXN_G.1
5BXN_U.1
5CGF_G.1
5CGF_U.1
5CGG_G.1
5CGG_U.1
5CGH_G.1
5CGH_U.1
5CGI_G.1
5CGI_U.1
5CZ4_G.1
5CZ4_U.1
5CZ5_G.1
5CZ5_U.1
5CZ6_G.1
5CZ6_U.1
5CZ7_G.1
5CZ7_U.1
5CZ8_G.1
5CZ8_U.1
5CZ9_G.1
5CZ9_U.1
5CZA_G.1
5CZA_U.1
5D0S_G.1
5D0S_U.1
5D0T_G.1
5D0T_U.1
5D0V_G.1
5D0V_U.1
5D0W_G.1
5D0W_U.1
5D0X_G.1
5D0X_U.1
5D0Z_G.1
5D0Z_U.1
5DKI_G.1
5DKI_U.1
5DKJ_G.1
5DKJ_U.1
5FG7_G.1
5FG7_U.1
5FG9_G.1
5FG9_U.1
5FGA_G.1
5FGA_U.1
5FGD_G.1
5FGD_U.1
5FGE_G.1
5FGE_U.1
5FGF_G.1
5FGF_U.1
5FGG_G.1
5FGG_U.1
5FGH_G.1
5FGH_U.1
5FGI_G.1
5FGI_U.1
5FHS_G.1
5FHS_U.1
5JHR_G.1
5JHR_U.1
5JHS_G.1
5JHS_U.1
5L52_G.1
5L52_U.1
5L54_G.1
5L54_U.1
5L55_G.1
5L55_U.1
5L5A_G.1
5L5A_U.1
5L5B_G.1
5L5B_U.1
5L5D_G.1
5L5D_U.1
5L5E_G.1
5L5E_U.1
5L5F_G.1
5L5F_U.1
5L5H_G.1
5L5H_U.1
5L5I_G.1
5L5I_U.1
5L5J_G.1
5L5J_U.1
5L5O_G.1
5L5O_U.1
5L5P_G.1
5L5P_U.1
5L5Q_G.1
5L5Q_U.1
5L5R_G.1
5L5R_U.1
5L5S_G.1
5L5S_U.1
5L5T_G.1
5L5T_U.1
5L5U_G.1
5L5U_U.1
5L5V_G.1
5L5V_U.1
5L5W_G.1
5L5W_U.1
5L5X_G.1
5L5X_U.1
5L5Y_G.1
5L5Y_U.1
5L5Z_G.1
5L5Z_U.1
5L60_G.1
5L60_U.1
5L61_G.1
5L61_U.1
5L62_G.1
5L62_U.1
5L63_G.1
5L63_U.1
5L64_G.1
5L64_U.1
5L65_G.1
5L65_U.1
5L66_G.1
5L66_U.1
5L67_G.1
5L67_U.1
5L68_G.1
5L68_U.1
5L69_G.1
5L69_U.1
5L6A_G.1
5L6A_U.1
5L6B_G.1
5L6B_U.1
5L6C_G.1
5L6C_U.1
5LAI_G.1
5LAI_U.1
5LAJ_G.1
5LAJ_U.1
5LTT_G.1
5LTT_U.1
5M2B_G.1
5M2B_U.1
5MP9_A.1
5MP9_a.1
5MPA_A.1
5MPA_a.1
5MPB_A.1
5MPB_a.1
5MPC_A.1
5MPC_a.1
5NIF_A.1
5NIF_O.1
5WVI_A.1
5WVI_c.1
5WVK_A.1
5WVK_c.1
6EF3_A.1
6G7F_G.1
6G7F_U.1
6G8M_G.1
6G8M_U.1
6G8N_G.1
6G8N_U.1
6GOP_G.1
6GOP_U.1
6H39_G.1
6H39_U.1
6HTB_G.1
6HTB_U.1
6HTC_G.1
6HTC_U.1
6HTD_G.1
6HTD_U.1
6HTP_G.1
6HTP_U.1
6HTR_G.1
6HTR_U.1
6HUB_G.1
6HUB_U.1
6HUC_G.1
6HUC_U.1
6HUQ_G.1
6HUQ_U.1
6HUU_G.1
6HUU_U.1
6HUV_G.1
6HUV_U.1
6HV3_G.1
6HV3_U.1
6HV4_G.1
6HV4_U.1
6HV5_G.1
6HV5_U.1
6HV7_G.1
6HV7_U.1
6HVA_G.1
6HVA_U.1
6HVR_G.1
6HVR_U.1
6HVS_G.1
6HVS_U.1
6HVT_G.1
6HVT_U.1
6HVU_G.1
6HVU_U.1
6HVV_G.1
6HVV_U.1
6HVW_G.1
6HVW_U.1
6HVX_G.1
6HVX_U.1
6HVY_G.1
6HVY_U.1
6HW0_G.1
6HW0_U.1
6HW3_G.1
6HW3_U.1
6HW4_G.1
6HW4_U.1
6HW5_G.1
6HW5_U.1
6HW6_G.1
6HW6_U.1
6HW7_G.1
6HW7_U.1
6HW8_G.1
6HW8_U.1
6HW9_G.1
6HW9_U.1
6HWA_G.1
6HWA_U.1
6HWB_G.1
6HWB_U.1
6HWC_G.1
6HWC_U.1
6HWD_G.1
6HWD_U.1
6HWE_G.1
6HWE_U.1
6HWF_G.1
6HWF_U.1
6J2C_A.1
6J2C_c.1
6J2N_A.1
6J2N_c.1
6J2Q_A.1
6J2Q_c.1
6J2X_A.1
6J2X_c.1
6J30_A.1
6J30_c.1
6ZOU_G.1
6ZOU_U.1
6ZP6_G.1
6ZP6_U.1
6ZP8_G.1
6ZP8_U.1
7LS5_A.1
7LS5_O.1
7LS6_A.1
7LSX_A.1
P21243.1