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RPN14 Rpn14p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852880, updated on 25-Jan-2022

Summary

Gene symbol
RPN14
Gene description
Rpn14p
Primary source
SGD:S000002972
Locus tag
YGL004C
See related
AllianceGenome:SGD:S000002972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein folding chaperone. Involved in proteasome regulatory particle assembly and ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Orthologous to human PAAF1 (proteasomal ATPase associated factor 1). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See RPN14 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (490703..491956, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene calcium-transporting ATPase PMC1 Neighboring gene Golgi transport complex subunit COG7 Neighboring gene Cdh1p Neighboring gene Erp6p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Rpn14p
NP_011511.3
  • Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    490703..491956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180869.3NP_011511.3  TPA: Rpn14p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011511.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53196
    Conserved Domains (2) summary
    sd00039
    Location:96133
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:133357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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