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RSR1 Ras family GTPase RSR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853056, updated on 17-May-2024

Summary

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Gene symbol
RSR1
Gene description
Ras family GTPase RSR1
Primary source
FungiDB:YGR152C
Locus tag
YGR152C
See related
SGD:S000003384; AllianceGenome:SGD:S000003384; VEuPathDB:YGR152C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BUD1
Summary
Enables GTPase activity. Involved in several processes, including cellular bud site selection; positive regulation of Rho guanyl-nucleotide exchange factor activity; and positive regulation of Rho protein signal transduction. Located in several cellular components, including cell division site; cellular bud neck; and vacuolar membrane. Part of incipient cellular bud site. Orthologous to several human genes including RAP1A (RAP1A, member of RAS oncogene family) and RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RSR1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (794674..795492, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ccm1p Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery. Wang X, et al. J Cell Biol, 2022 Dec 5. PMID 36156058, Free PMC Article
  2. Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast. Park HO, et al. J Biol Chem, 2002 Jul 26. PMID 12058023
  3. Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation. Holden JL, et al. J Biol Chem, 1991 Sep 15. PMID 1910037
  4. Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae. Clark-Cotton MR, et al. Mol Biol Cell, 2021 May 1. PMID 33689470, Free PMC Article
  5. Tracking shallow chemical gradients by actin-driven wandering of the polarization site. Dyer JM, et al. Curr Biol, 2013 Jan 7. PMID 23200992, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.
    Title: Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic G1 phase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in incipient cellular bud site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of polarized growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ras family GTPase RSR1
NP_011668.3
  • Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    794674..795492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181281.3 → NP_011668.3  TPA: Ras family GTPase RSR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011668.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUT2, P13856
    UniProtKB/TrEMBL
    A0A6A5PYW2, C8Z946, G2WEN2, N1P2D7
    Conserved Domains (1) summary
    cd04177
    Location:3 → 166
    RSR1; RSR1/Bud1p family GTPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13856.1

Gene LinkOut

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