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GCN5 histone acetyltransferase GCN5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853167, updated on 7-Jul-2019

Summary

Gene symbol
GCN5
Gene description
histone acetyltransferase GCN5
Primary source
SGD:S000003484
Locus tag
YGR252W
Gene type
protein coding
RNA name
histone acetyltransferase GCN5
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AAS104; ADA4; KAT2; SWI9

Genomic context

See GCN5 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (996869..998188)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rie1p Neighboring gene Nop19p Neighboring gene proteasome core particle subunit alpha 5 Neighboring gene phosphopyruvate hydratase ENO1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GCN5 gene: The GCN5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
H3 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
H3 histone acetyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
H3 histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 acetylation IEA
Inferred from Electronic Annotation
more info
 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription elongation from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription elongation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone acetyltransferase GCN5
NP_011768.1
  • Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    996869..998188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181381.1NP_011768.1  TPA: histone acetyltransferase GCN5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03330
    Conserved Domains (1) summary
    COG5076
    Location:77439
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
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