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ENO1 phosphopyruvate hydratase ENO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853169, updated on 9-Jun-2019

Summary

Gene symbol
ENO1
Gene description
phosphopyruvate hydratase ENO1
Primary source
SGD:S000003486
Locus tag
YGR254W
Gene type
protein coding
RNA name
phosphopyruvate hydratase ENO1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSP48

Genomic context

See ENO1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1000927..1002240)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase GCN5 Neighboring gene proteasome core particle subunit alpha 5 Neighboring gene putative N,N-dimethylaniline monooxygenase COQ6 Neighboring gene tRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ENO1 gene: The ENO1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
lyase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
phosphopyruvate hydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
gluconeogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol HDA PubMed 
fungal-type vacuole IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
PubMed 
phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
 
plasma membrane HDA PubMed 

General protein information

Preferred Names
phosphopyruvate hydratase ENO1
NP_011770.3
  • Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1000927..1002240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181383.3NP_011770.3  TPA: phosphopyruvate hydratase ENO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011770.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00924
    Conserved Domains (1) summary
    cl27211
    Location:1430
    Enolase_N; Enolase, N-terminal domain
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