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PRE3 proteasome core particle subunit beta 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853456, updated on 13-Apr-2024

Summary

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Gene symbol
PRE3
Gene description
proteasome core particle subunit beta 1
Primary source
SGD:S000003538
Locus tag
YJL001W
See related
AllianceGenome:SGD:S000003538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRL21
Summary
Enables endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to several human genes including PSMB6 (proteasome 20S subunit beta 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_001142.9 (435163..435926)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Cox16p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Neighboring gene Avt1p Neighboring gene rRNA-processing protein MPP10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational constraints for protein self-cleavage in the proteasome. Ditzel L, et al. J Mol Biol, 1998 Jun 26. PMID 9642094
  2. PRE3, highly homologous to the human major histocompatibility complex-linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity. Enenkel C, et al. FEBS Lett, 1994 Mar 21. PMID 7907993
  3. Mutations in the yeast proteasome beta-type subunit Pre3 uncover position-dependent effects on proteasomal peptidase activity and in vivo function. Gueckel R, et al. J Biol Chem, 1998 Jul 31. PMID 9677364
  4. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Ramos PC, et al. Cell, 1998 Feb 20. PMID 9491890
  5. A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome. Huber EM, et al. Nat Commun, 2016 Mar 11. PMID 26964885, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
  
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome core particle subunit beta 1
NP_012533.1
  • Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    435163..435926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181435.1 → NP_012533.1  TPA: proteasome core particle subunit beta 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012533.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH4, P38624
    UniProtKB/TrEMBL
    A6ZPW6, B3LQ98, C7GUU0, D3UF68, G2WH09, N1P0Z6
    Conserved Domains (1) summary
    cd03762
    Location:20 → 204
    proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3JCO_3.1
3JCO_h.1
3JCP_3.1
3JCP_h.1
3WXR_H.1
3WXR_V.1
4X6Z_H.1
4X6Z_V.1
5MP9_1.1
5MP9_h.1
5MPA_1.1
5MPA_h.1
5MPB_1.1
5MPB_h.1
5MPC_1.1
5MPC_h.1
5NIF_H.1
5NIF_V.1
5WVI_1.1
5WVI_b.1
5WVK_1.1
5WVK_b.1
6EF3_1.1
6J2C_1.1
6J2C_b.1
6J2N_1.1
6J2N_b.1
6J2Q_1.1
6J2Q_b.1
6J2X_1.1
6J2X_b.1
6J30_1.1
6J30_b.1
P38624.2

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