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CDC8 bifunctional thymidylate/uridylate kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853520, updated on 11-Apr-2024

Summary

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Gene symbol
CDC8
Gene description
bifunctional thymidylate/uridylate kinase
Primary source
SGD:S000003818
Locus tag
YJR057W
See related
AllianceGenome:SGD:S000003818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nucleoside diphosphate kinase activity; thymidylate kinase activity; and uridylate kinase activity. Involved in nucleotide metabolic process. Located in cytoplasm and nucleus. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (544062..544712)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Tyr Neighboring gene Aps2p Neighboring gene protein kinase PTK2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Budding yeast mutants showing constitutive basal levels of expression of DNA synthesis genes. Johnston LH, et al. Mol Gen Genet, 1993 Jul. PMID 8341263
  2. The structure of uridylate kinase with its substrates, showing the transition state geometry. Müller-Dieckmann HJ, et al. J Mol Biol, 1994 Feb 11. PMID 8107116
  3. Purification of the cdc8 protein of Saccharomyces cerevisiae by complementation in an aphidicolin-sensitive in vitro DNA replication system. Kuo CL, et al. Proc Natl Acad Sci U S A, 1982 Jul. PMID 6812044, Free PMC Article
  4. Evidence for participation of a multiprotein complex in yeast DNA replication in vitro. Jazwinski SM, et al. J Biol Chem, 1984 Jun 10. PMID 6373767
  5. Saccharomyces cerevisiae CDC8 gene and its product. Birkenmeyer LG, et al. Mol Cell Biol, 1984 Apr. PMID 6371491, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UMP/dUMP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside diphosphate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidylate kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables thymidylate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dTDP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dTDP biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dTDP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTTP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dTTP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dUDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional thymidylate/uridylate kinase
NP_012591.1
  • Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    544062..544712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181715.1 → NP_012591.1  TPA: bifunctional thymidylate/uridylate kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWM8, P00572
    UniProtKB/TrEMBL
    A0A8H4C103, A6ZQ16, B3LQE6, B5VLL1, C7GME6, G2WH62
    Conserved Domains (1) summary
    cl17190
    Location:3 → 206
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00572.2

Gene LinkOut

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