PMT4 dolichyl-phosphate-mannose-protein mannosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PMT4
Gene description: dolichyl-phosphate-mannose-protein mannosyltransferase
Primary source: SGD:S000003904
Locus tag: YJR143C
See related: AllianceGenome:SGD:S000003904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation and regulation of endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex. Used to study Walker-Warburg syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy; cleft lip; lissencephaly; and muscular dystrophy (multiple). Orthologous to human POMT1 (protein O-mannosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (698326..700614, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results demonstrate functional and biochemical similarities between POMT1 and its orthologue from bakers' yeast Pmt4.
Title: Functional Similarities between the Protein O-Mannosyltransferases Pmt4 from Bakers' Yeast and Human POMT1.
Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases.
Title: Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of endoplasmic reticulum unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyl-phosphate-mannose-protein mannosyltransferase

NP_012677.1

EC 2.4.1.109

Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

698326..700614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181801.1 → NP_012677.1 TPA: dolichyl-phosphate-mannose-protein mannosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012677.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWW2, P46971

UniProtKB/TrEMBL

A0A8H4FCB1, C8ZBU3, N1P1U5

Conserved Domains (1) summary

COG1928
Location:32 → 755

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]