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SRX1 sulfiredoxin [ Saccharomyces cerevisiae S288C ]

Gene ID: 853776, updated on 13-Apr-2024

Summary

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Gene symbol
SRX1
Gene description
sulfiredoxin
Primary source
SGD:S000001569
Locus tag
YKL086W
See related
AllianceGenome:SGD:S000001569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sulfiredoxin activity. Involved in cellular response to oxidative stress. Located in cytoplasm and nucleus. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (278281..278664)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene cytochrome c1 heme lyase CYT2 Neighboring gene malate dehydrogenase MDH1 Neighboring gene Hot13p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo. Boukhenouna S, et al. Antioxid Redox Signal, 2015 Mar 20. PMID 25387359, Free PMC Article
  2. Probing the mechanism of the peroxiredoxin decamer interaction with its reductase sulfiredoxin from the single molecule to the solution scale. Beaussart A, et al. Nanoscale Horiz, 2022 May 3. PMID 35234779
  3. Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin. Moon JC, et al. Biochem Biophys Res Commun, 2013 Mar 8. PMID 23396059
  4. Molecular and functional characterization of sulfiredoxin homologs from higher plants. Liu XP, et al. Cell Res, 2006 Mar. PMID 16541127
  5. Catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide sulfiredoxin intermediate that is reduced by thioredoxin. Roussel X, et al. J Biol Chem, 2009 Nov 27. PMID 19801666, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study provides both in vitro and in vivo evidence of the role of GSH as the primary reducer of 1-Cys Srxs.
    Title: Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo.
  2. these findings suggest that Srx1 regulates YPrx1 function and structure in yeast cells through a direct interaction.
    Title: Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin.
  3. These data collectively emphasize the significance of sulfiredoxin, peroxiredoxin, and mitochondrial respiratory chain to respond to and to protect from 100% O(2).
    Title: Significance of sulfiredoxin/peroxiredoxin and mitochondrial respiratory chain in response to and protection from 100% O(2) in Saccharomyces cerevisiae.
  4. Results show that an oxidized sulfiredoxin under disulfide state is formed between the catalytic Cys(84) and Cys(48), and this oxidized is reduced selectively by thioredoxin.
    Title: Catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide sulfiredoxin intermediate that is reduced by thioredoxin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfiredoxin activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfiredoxin
NP_012837.1
  • Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    278281..278664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179652.1 → NP_012837.1  TPA: sulfiredoxin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012837.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK2, P36077
    UniProtKB/TrEMBL
    A0A6A5PU79, A6ZZN2, B3LR06, C7GVM4, C8ZC88, G2WHU7, N1P067
    Conserved Domains (1) summary
    COG5119
    Location:1 → 127
    COG5119; Uncharacterized protein, contains ParB-like nuclease domain [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36077.1

Gene LinkOut

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