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Tdrd7 tudor domain containing 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85425, updated on 13-Apr-2024

Summary

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Official Symbol
Tdrd7provided by RGD
Official Full Name
tudor domain containing 7provided by RGD
Primary source
RGD:619724
See related
Ensembl:ENSRNOG00000055779 AllianceGenome:RGD:619724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pctaire2bp
Summary
Enables protein N-terminus binding activity. Predicted to be involved in several processes, including gamete generation; lens development in camera-type eye; and piRNA metabolic process. Predicted to act upstream of or within germ cell development. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 329.0), Lung (RPKM 101.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65034317..65108165)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60238742..60312548)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (61557909..61631719)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene STRA6-like Neighboring gene coiled-coil domain containing 180 Neighboring gene uncharacterized LOC120102865 Neighboring gene uncharacterized LOC120102866 Neighboring gene tropomodulin 1 Neighboring gene thiosulfate sulfurtransferase like domain containing 2 Neighboring gene nuclear cap binding protein subunit 1 Neighboring gene XPA, DNA damage recognition and repair factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Hirose T, et al. Eur J Biochem, 2000 Apr. PMID 10727952
  2. Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Hosokawa M, et al. Dev Biol, 2007 Jan 1. PMID 17141210
  3. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Lachke SA, et al. Science, 2011 Mar 25. PMID 21436445, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93175

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in lens fiber cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lens morphogenesis in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in lens morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in lens morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule ISO
Inferred from Sequence Orthology
more info
  
located_in chromatoid body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tudor domain-containing protein 7
Names
PCTAIRE2-binding protein
trap
tudor repeat associator with PCTAIRE-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138871.2 → NP_620226.1  tudor domain-containing protein 7

    See identical proteins and their annotated locations for NP_620226.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5FVD0, Q9R1R4
    UniProtKB/TrEMBL
    A0A8L2R2S9, A6IJA7
    Related
    ENSRNOP00000068568.1, ENSRNOT00000085738.2
    Conserved Domains (5) summary
    cd04508
    Location:722 → 767
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:250 → 316
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:355 → 419
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:924 → 1041
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    65034317..65108165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238108.4 → XP_006238170.1  tudor domain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R2S9, A0A8L2R3M8
    Related
    ENSRNOP00000070639.2
    Conserved Domains (5) summary
    cd04508
    Location:728 → 773
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:256 → 322
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:361 → 425
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:38 → 124
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:930 → 1047
    TUDOR; Tudor domain

  2. XM_006238107.4 → XP_006238169.1  tudor domain-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R2S9
    Conserved Domains (5) summary
    cd04508
    Location:755 → 800
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:283 → 349
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:388 → 452
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:38 → 124
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:957 → 1074
    TUDOR; Tudor domain

  3. XM_008763704.1 → XP_008761926.1  tudor domain-containing protein 7 isoform X4

    See identical proteins and their annotated locations for XP_008761926.1

    UniProtKB/TrEMBL
    A0A8L2R2S9
    Related
    ENSRNOP00000070634.2, ENSRNOT00000089938.2
    Conserved Domains (5) summary
    cd04508
    Location:695 → 740
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:223 → 289
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:328 → 392
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:897 → 1014
    TUDOR; Tudor domain

  4. XM_017593667.3 → XP_017449156.1  tudor domain-containing protein 7 isoform X3

    UniProtKB/Swiss-Prot
    Q5FVD0, Q9R1R4
    UniProtKB/TrEMBL
    A0A8L2R2S9, A6IJA7
    Conserved Domains (5) summary
    cd04508
    Location:722 → 767
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:250 → 316
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:355 → 419
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:924 → 1041
    TUDOR; Tudor domain

  5. XM_063288514.1 → XP_063144584.1  tudor domain-containing protein 7 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1R4.1 GenPept UniProtKB/Swiss-Prot:Q9R1R4

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