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LSC1 succinate--CoA ligase (GDP-forming) subunit alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 854310, updated on 7-Apr-2024

Summary

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Gene symbol
LSC1
Gene description
succinate--CoA ligase (GDP-forming) subunit alpha
Primary source
SGD:S000005668
Locus tag
YOR142W
See related
AllianceGenome:SGD:S000005668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables succinate-CoA ligase (ADP-forming) activity. Involved in succinyl-CoA metabolic process. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (593057..594046)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sfl1p Neighboring gene Arp8p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes of succinyl-CoA ligase from Saccharomyces cerevisiae. Przybyla-Zawislak B, et al. Eur J Biochem, 1998 Dec 1. PMID 9874242
  2. Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix. Garg S, et al. Genome Biol Evol, 2015 Sep 2. PMID 26338186, Free PMC Article
  3. Engineering an NADPH/NADP(+) Redox Biosensor in Yeast. Zhang J, et al. ACS Synth Biol, 2016 Dec 16. PMID 27419466
  4. Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions. Taylor MB, et al. PLoS Genet, 2015 Oct. PMID 26484664, Free PMC Article
  5. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Przybyla-Zawislak B, et al. Genetics, 1999 May. PMID 10224250, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in succinyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
succinate--CoA ligase (GDP-forming) subunit alpha
NP_014785.3
  • Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    593057..594046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183561.3 → NP_014785.3  TPA: succinate--CoA ligase (GDP-forming) subunit alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014785.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2J8, P53598
    UniProtKB/TrEMBL
    A0A6A5Q2P0, A6ZNY7, B3LJI0, B5VS30, C7GN81, C8ZIA4, G2WN15, N1NX04
    Conserved Domains (1) summary
    PTZ00187
    Location:24 → 327
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53598.1

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