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DCLK3 doublecortin like kinase 3 [ Homo sapiens (human) ]

Gene ID: 85443, updated on 5-Sep-2021

Summary

Official Symbol
DCLK3provided by HGNC
Official Full Name
doublecortin like kinase 3provided by HGNC
Primary source
HGNC:HGNC:19005
See related
Ensembl:ENSG00000163673 MIM:613167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLR; DCK3; DCDC3C; DCAMKL3
Expression
Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues See more
Orthologs
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Genomic context

See DCLK3 in Genome Data Viewer
Location:
3p22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (36712421..36764553, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36753913..36781352, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 227 Neighboring gene Sharpr-MPRA regulatory region 13437 Neighboring gene uncharacterized LOC105377029 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase DCLK3
Names
CLICK-I,II-related
doublecortin and CaM kinase-like 3
doublecortin domain-containing protein 3C
doublecortin-like and CAM kinase-like 3
NP_001381601.1
NP_208382.1
XP_011532470.1
XP_011532471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394672.2NP_001381601.1  serine/threonine-protein kinase DCLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105749
    Conserved Domains (2) summary
    cd14185
    Location:524781
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)
    cd16111
    Location:93177
    DCX_DCLK3; Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3)
  2. NM_033403.1NP_208382.1  serine/threonine-protein kinase DCLK3 isoform 2

    See identical proteins and their annotated locations for NP_208382.1

    Status: VALIDATED

    Source sequence(s)
    AB051552, AC105749, AK122988, DB075681, DR000236
    Consensus CDS
    CCDS43064.1
    UniProtKB/Swiss-Prot
    Q9C098
    UniProtKB/TrEMBL
    B3KVM3
    Related
    ENSP00000394484.2, ENST00000416516.2
    Conserved Domains (2) summary
    smart00220
    Location:356613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14185
    Location:355612
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    36712421..36764553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534168.3XP_011532470.1  serine/threonine-protein kinase DCLK3 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:356557
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:355556
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011534169.1XP_011532471.1  serine/threonine-protein kinase DCLK3 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:356489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:355488
    PKc_like; Protein Kinases, catalytic domain
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