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DNAJC5B DnaJ heat shock protein family (Hsp40) member C5 beta [ Homo sapiens (human) ]

Gene ID: 85479, updated on 5-Mar-2024

Summary

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Official Symbol
DNAJC5Bprovided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C5 betaprovided by HGNC
Primary source
HGNC:HGNC:24138
See related
Ensembl:ENSG00000147570 MIM:613945; AllianceGenome:HGNC:24138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSP-beta
Summary
This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins that is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. The encoded protein, together with heat shock protein 70, is thought to regulate the proper folding of other proteins. The orthologous mouse protein is membrane-associated and is targeted to the trans-golgi network. [provided by RefSeq, Mar 2017]
Expression
Biased expression in testis (RPKM 18.0), lymph node (RPKM 1.5) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See DNAJC5B in Genome Data Viewer
Location:
8q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66014978..66101245)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66440668..66526936)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (66927213..67013480)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66753999-66754568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66754569-66755137 Neighboring gene MPRA-validated peak7056 silencer Neighboring gene PDE7A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:66842558-66843076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:66843077-66843595 Neighboring gene uncharacterized LOC107986950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27469 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:66862529-66863728 Neighboring gene uncharacterized LOC105375883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27470 Neighboring gene Sharpr-MPRA regulatory region 3041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19250 Neighboring gene Sharpr-MPRA regulatory region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27472 Neighboring gene H3K27ac hESC enhancers GRCh37_chr8:67025273-67025924 and GRCh37_chr8:67025925-67026577 Neighboring gene tRNA-Tyr (anticodon GTA) 5-1 Neighboring gene tRNA-Tyr (anticodon GTA) 5-2 Neighboring gene tripartite motif containing 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines. Mirzaei MR, et al. Iran J Basic Med Sci, 2016 Feb. PMID 27081464, Free PMC Article
  2. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. Boal F, et al. Biochim Biophys Acta, 2007 Feb. PMID 17034881
  3. Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity. Braga ACS, et al. PLoS One, 2017. PMID 29182667, Free PMC Article
  4. Human DNAJ in cancer and stem cells. Sterrenberg JN, et al. Cancer Lett, 2011 Dec 22. PMID 21925790
  5. Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain. Gundersen CB, et al. Brain Res, 2010 May 21. PMID 20338151

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suggest that HSPB8 may act as an intracellular factor against hepatitis C virus replication and that DNAJC5B has the same function, with more relevant results for genotype 3
    Title: Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity.
  2. These results suggest a possible correlation between the specific membrane targeting and the palmitoylation level of CSPs.
    Title: Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
EBI GWAS Catalog
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 5B
Names
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
beta cysteine string protein
beta-CSP
cysteine string protein beta
dnaJ homolog subfamily C member X
testicular tissue protein Li 55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053039.1 RefSeqGene

    Range
    11571..91263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001349432.2 → NP_001336361.1  dnaJ homolog subfamily C member 5B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084082, AF368276, BG701336, BU627018
    Consensus CDS
    CCDS6183.1
    UniProtKB/Swiss-Prot
    Q969Y8, Q9UF47
    UniProtKB/TrEMBL
    A0A024R7Z1
    Conserved Domains (1) summary
    PRK10767
    Location:21 → 84
    PRK10767; chaperone protein DnaJ; Provisional

  2. NM_033105.6 → NP_149096.2  dnaJ homolog subfamily C member 5B

    See identical proteins and their annotated locations for NP_149096.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084082, AF368276, BG701336, BU627018
    Consensus CDS
    CCDS6183.1
    UniProtKB/Swiss-Prot
    Q969Y8, Q9UF47
    UniProtKB/TrEMBL
    A0A024R7Z1
    Related
    ENSP00000276570.5, ENST00000276570.10
    Conserved Domains (1) summary
    PRK10767
    Location:21 → 84
    PRK10767; chaperone protein DnaJ; Provisional

RNA

  1. NR_146171.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC084082, AL133660

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    66014978..66101245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517620.3 → XP_011515922.1  dnaJ homolog subfamily C member 5B isoform X1

    Conserved Domains (2) summary
    COG0484
    Location:21 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:20 → 81
    DnaJ; DnaJ domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    66440668..66526936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361411.1 → XP_054217386.1  dnaJ homolog subfamily C member 5B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UF47.2 GenPept UniProtKB/Swiss-Prot:Q9UF47

Gene LinkOut

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