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ERG13 hydroxymethylglutaryl-CoA synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854913, updated on 7-Nov-2021

Summary

Gene symbol
ERG13
Gene description
hydroxymethylglutaryl-CoA synthase
Primary source
SGD:S000004595
Locus tag
YML126C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HMGS
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Genomic context

See ERG13 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (19060..20535, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Msc1p Neighboring gene Rsc9p Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB3 Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ERG13 gene: The ERG13 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase
NP_013580.1
  • 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    19060..20535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182489.1NP_013580.1  TPA: hydroxymethylglutaryl-CoA synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54839
    Conserved Domains (1) summary
    TIGR01833
    Location:45490
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
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