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CYB2 Cyb2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854950, updated on 5-May-2019

Summary

Gene symbol
CYB2
Gene description
Cyb2p
Primary source
SGD:S000004518
Locus tag
YML054C
Gene type
protein coding
RNA name
Cyb2p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FCB2

Genomic context

See CYB2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (165533..167308, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene IMP dehydrogenase IMD4 Neighboring gene ncRNA Neighboring gene signal peptidase complex subunit SPC2 Neighboring gene hypothetical protein Neighboring gene tRNA

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the CYB2 gene: The CYB2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-lactate dehydrogenase (cytochrome) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-lactate dehydrogenase (cytochrome) activity IDA
Inferred from Direct Assay
more info
PubMed 
L-lactate dehydrogenase (cytochrome) activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
respiratory chain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cyb2p
NP_013658.1
  • Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    165533..167308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182412.1NP_013658.1  TPA: Cyb2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013658.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00175
    Conserved Domains (2) summary
    COG5274
    Location:34187
    CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
    cd02922
    Location:206555
    FCB2_FMN; Flavocytochrome b2 (FCB2) FMN-binding domain. FCB2 (AKA L-lactate:cytochrome c oxidoreductase) is a respiratory enzyme located in the intermembrane space of fungal mitochondria which catalyzes the oxidation of L-lactate to pyruvate. FCB2 also ...
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