SNZ1 pyridoxine biosynthesis protein SNZ1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SNZ1
Gene description: pyridoxine biosynthesis protein SNZ1
Primary source: FungiDB:YMR096W
Locus tag: YMR096W
See related: SGD:S000004702; AllianceGenome:SGD:S000004702
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity. Contributes to glutaminase activity. Involved in pyridoxine biosynthetic process. Part of glutaminase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SNZ1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (458408..459301)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structures of Snz1 (Pdx1/Snz1) in apo- (2.3 A), G3P- (1.8 A), and PLP- (2.2 A) bound forms; structural & biochemical analysis allow assignment of PLP-formation site, G3P-binding site & G3P-transfer site
Title: Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1.
Pho4 binding to the SNZ1/SNO1 promoter is accompanied by alterations in chromatin structure, and Rpd3 histone deacetylase is required for the proper timing of SNZ1/SNO1 expression, while Asf1 histone chaperone is indispensable for their expression.
Title: Transcriptional repression by the Pho4 transcription factor controls the timing of SNZ1 expression.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables amine-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyridoxine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pyridoxine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin B6 biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin B6 biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of glutaminase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: pyridoxine biosynthesis protein SNZ1

NP_013814.1

EC 4.3.3.6

Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

458408..459301

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182596.1 → NP_013814.1 TPA: pyridoxine biosynthesis protein SNZ1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013814.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZR9, Q03148

UniProtKB/TrEMBL

A0A8H4BWD7, A6ZMF3, B3LLY7, B5VPM3, C7GL30, C8ZEU8, G2WKE4, N1P0A8

Conserved Domains (1) summary

TIGR00343
Location:8 → 297

TIGR00343; pyridoxal 5'-phosphate synthase, synthase subunit Pdx1