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ARG4 argininosuccinate lyase ARG4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856411, updated on 13-Apr-2024

Summary

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Gene symbol
ARG4
Gene description
argininosuccinate lyase ARG4
Primary source
SGD:S000001060
Locus tag
YHR018C
See related
AllianceGenome:SGD:S000001060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables argininosuccinate lyase activity. Involved in arginine biosynthetic process via ornithine. Located in cytosol. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (140011..141402, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ysc84p Neighboring gene Ysc83p Neighboring gene asparagine--tRNA ligase DED81 Neighboring gene proline--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ethylene production in relation to nitrogen metabolism in Saccharomyces cerevisiae. Johansson N, et al. FEMS Yeast Res, 2014 Nov. PMID 25195797
  2. DNA motif associated with meiotic double-strand break regions in Saccharomyces cerevisiae. Blumental-Perry A, et al. EMBO Rep, 2000 Sep. PMID 11256605, Free PMC Article
  3. Competitive inactivation of a double-strand DNA break site involves parallel suppression of meiosis-induced changes in chromatin configuration. Ohta K, et al. Nucleic Acids Res, 1999 May 15. PMID 10219090, Free PMC Article
  4. Mitotic recombination and localized DNA double-strand breaks are induced after 8-methoxypsoralen and UVA irradiation in Saccharomyces cerevisiae. Dardalhon M, et al. Curr Genet, 1998 Jul. PMID 9683673
  5. Sensing of DNA non-homology lowers the initiation of meiotic recombination in yeast. Rocco V, et al. Genes Cells, 1996 Jul. PMID 9078391

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gcn4p stimulates binding of Cyc8p/Tup1p at the 3' end of the ARG4 gene.
    Title: Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables argininosuccinate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables argininosuccinate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables argininosuccinate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine biosynthetic process via ornithine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginine biosynthetic process via ornithine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
argininosuccinate lyase ARG4
NP_011882.1
  • Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    140011..141402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179148.1 → NP_011882.1  TPA: argininosuccinate lyase ARG4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKW3, P04076
    UniProtKB/TrEMBL
    A0A6A5PVI0, A6ZSS2, B5VJU5, C7GXA8, C8ZA85, G2WF86, N1P375
    Conserved Domains (1) summary
    TIGR00838
    Location:8 → 463
    argH; argininosuccinate lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04076.2

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