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NOP14 NOP14 nucleolar protein [ Homo sapiens (human) ]

Gene ID: 8602, updated on 7-Apr-2024

Summary

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Official Symbol
NOP14provided by HGNC
Official Full Name
NOP14 nucleolar proteinprovided by HGNC
Primary source
HGNC:HGNC:16821
See related
Ensembl:ENSG00000087269 MIM:611526; AllianceGenome:HGNC:16821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UTP2; NOL14; C4orf9; RES425; RES4-25
Summary
This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in lymph node (RPKM 10.9), appendix (RPKM 9.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4p16.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2937936..2963406, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2936399..2962082, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2939663..2965133, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2863877-2864589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:2864590-2865301 Neighboring gene adducin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876343-2876870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876871-2877396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2923771-2924668 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2924669-2925564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2925565-2926460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2927877-2928392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene RNA, U6 small nuclear 204, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer. Lu C, et al. BMC Gastroenterol, 2022 Apr 26. PMID 35473611, Free PMC Article
  2. NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway. Zhu X, et al. Eur J Histochem, 2021 Jul 2. PMID 34218653, Free PMC Article
  3. NOP14 promotes proliferation and metastasis of pancreatic cancer cells. Zhou B, et al. Cancer Lett, 2012 Sep 28. PMID 22425761
  4. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. Pribill I, et al. Somat Cell Mol Genet, 1997 Nov. PMID 9661704
  5. A homozygous NOP14 variant is likely to cause recurrent pregnancy loss. Suzuki T, et al. J Hum Genet, 2018 Apr. PMID 29440706

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
    Title: NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
  2. Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
    Title: Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
  3. NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3beta/beta-catenin signaling pathway.
    Title: NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.
  4. CCND1, DNMT3B and NOP14 were identified as direct targets of miR-502-5p.
    Title: CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
  5. we identified an identical homozygous NOP14 variant as a possible contributing factor for RPL in two Iranian families.
    Title: A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.
  6. Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors
    Title: Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.
  7. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway.
    Title: NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.
  8. our study provides new evidence for NOP14 in regulating PC cell proliferation and migration, and may provide new insights for clinical diagnosis and therapy.
    Title: NOP14 promotes proliferation and metastasis of pancreatic cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of 90S preribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Noc4p-Nop14p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc4p-Nop14p complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleolar protein 14
Names
NOP14 nucleolar protein homolog
probable nucleolar complex protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291978.2 → NP_001278907.1  nucleolar protein 14 isoform 1

    See identical proteins and their annotated locations for NP_001278907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025692, AK292939
    Consensus CDS
    CCDS33945.1
    UniProtKB/Swiss-Prot
    D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6
    UniProtKB/TrEMBL
    A8KA74
    Related
    ENSP00000405068.2, ENST00000416614.7
    Conserved Domains (2) summary
    pfam04147
    Location:20 → 846
    Nop14; Nop14-like family
    cl03951
    Location:202 → 321
    CDC37_N; Cdc37 N terminal kinase binding

  2. NM_001291979.2 → NP_001278908.1  nucleolar protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001278908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK025692, AK292939, BC026035
    Consensus CDS
    CCDS77893.1
    UniProtKB/TrEMBL
    E9PFK5
    Related
    ENSP00000381146.4, ENST00000398071.4
    Conserved Domains (2) summary
    pfam04147
    Location:20 → 776
    Nop14; Nop14-like family
    cl03951
    Location:202 → 321
    CDC37_N; Cdc37 N terminal kinase binding

  3. NM_003703.3 → NP_003694.1  nucleolar protein 14 isoform 1

    See identical proteins and their annotated locations for NP_003694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF040965, AK025692, AK292939
    Consensus CDS
    CCDS33945.1
    UniProtKB/Swiss-Prot
    D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6
    UniProtKB/TrEMBL
    A8KA74
    Related
    ENSP00000315674.6, ENST00000314262.10
    Conserved Domains (2) summary
    pfam04147
    Location:20 → 846
    Nop14; Nop14-like family
    cl03951
    Location:202 → 321
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    2937936..2963406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416338.1 → XP_047272294.1  nucleolar protein 14 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    2936399..2962082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351138.1 → XP_054207113.1  nucleolar protein 14 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78316.3 GenPept UniProtKB/Swiss-Prot:P78316

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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