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abpA actin binding protein A [ Dictyostelium discoideum AX4 ]

Gene ID: 8616670, updated on 23-Nov-2023

Summary

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Gene symbol
abpA
Gene description
actin binding protein A
Primary source
dictyBase:DDB_G0268632
Locus tag
DDB_G0268632
Gene type
protein coding
RNA name
alpha actinin
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0191133; DDBDRAFT_0216633; DDBDRAFT_0216634; DDB_0191133; DDB_0216633; DDB_0216634
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Genomic context

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Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_007087.3 (2137156..2139957)

Chromosome 1 - NC_007087.3Genomic Context describing neighboring genes Neighboring gene cGMP-specific phosphodiesterase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007087.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ca(2+)-binding domains in non-muscle type alpha-actinin: biochemical and genetic analysis. Witke W, et al. J Cell Biol, 1993 May. PMID 8486739, Free PMC Article
  2. Properties of the 120,000- and 95,000-dalton actin-binding proteins from Dictyostelium discoideum and their possible functions in assembling the cytoplasmic matrix. Condeelis J, et al. J Cell Biol, 1984 Jul. PMID 6746725, Free PMC Article
  3. Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells. Sultana H, et al. BMC Dev Biol, 2012 Jan 12. PMID 22239817, Free PMC Article
  4. Actin binding domains direct actin-binding proteins to different cytoskeletal locations. Washington RW, et al. BMC Cell Biol, 2008 Feb 13. PMID 18269770, Free PMC Article
  5. The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development. Rivero F, et al. J Cell Sci, 1996 Nov. PMID 8937986

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sorocarp development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in contractile vacuole IEA
Inferred from Electronic Annotation
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in macropinocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Names
actin binding protein A
actin bundling protein
alpha actinin
alpha actinin 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007087.3 Reference assembly

    Range
    2137156..2139957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_641887.1 → XP_646979.1  alpha actinin [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_646979.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P05095, Q55EP1
    Conserved Domains (5) summary
    COG5126
    Location:720 → 858
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00014
    Location:24 → 127
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:733 → 794
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:387 → 608
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:801 → 861
    EFhand_Ca_insen; Ca2+ insensitive EF hand
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q55EP1.1

Gene LinkOut

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