URI1 URI1 prefoldin like chaperone [Homo sapiens (human)] - Gene

Summary

Official Symbol: URI1provided by HGNC
Official Full Name: URI1 prefoldin like chaperoneprovided by HGNC
Primary source: HGNC:HGNC:13236
See related: Ensembl:ENSG00000105176 MIM:603494; AllianceGenome:HGNC:13236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RMP; URI; NNX3; C19orf2; PPP1R19
Summary: This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (29923657..30016612)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (32444098..32537026)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (30414564..30507519)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells.
Title: URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells.
HBx and c-MYC are involved in URI1 expression in HCC-B. URI1 expression may play important roles in the development and progression of HCC-B because HBx and c-MYC are well-known oncogenic factors in the virus and host
Title: HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma.
Collectively, these findings indicate that RMP promotes Epithelial-mesenchymal transition and hepatocellular carcinoma metastasis through NF-kappaB/CSN2/Snail pathway. These results suggest that RMP and p65 may serve as potential candidates of the targets in the treatment of metastatic hepatocellular carcinoma.
Title: RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma.
These findings suggest that URI1 has properties of a 'non-oncogene' that supports the oncogenic phenotype of those cancer cells that have evolved a dependency on this molecular chaperone system for survival
Title: Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1.
This work uncovers that URI-regulated OGT confers c-MYC-dependent survival functions in response to glucose fluctuations.
Title: Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.
Amplification of 19q12 CCNE1/URI was found in 10.4% (28/270) and was significantly associated with type II endometrial cancer (EC) high grade, advanced FIGO stage, and aberrant tumor supressor p53 expression.
Title: Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer.
that KAP1 phosphorylation is decreased following recruitment of PP2A by URI.
Title: URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.
RMP status in tumors may be a useful marker in estimating prognosis in patients with hepatocellular carcinoma and in assisting in the selection of patients who are likely to benefit from adjuvant TACE to prevent relapse.
Title: RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
High URI1 expression is associated with epithelial ovarian cancer.
Title: Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes.
Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival.
Title: Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC30870 (e-PCR)
- UniSTS:20484

px-16e8 (e-PCR)
- UniSTS:257330

RH45535 (e-PCR)
- UniSTS:92520

STS-R63092 (e-PCR)
- UniSTS:6003

SHGC-30736 (e-PCR)
- UniSTS:68735

RH12894 (e-PCR)
- UniSTS:5524

STS-Z41049 (e-PCR)
- UniSTS:9954

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to steroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein folding chaperone complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: unconventional prefoldin RPB5 interactor 1

Names: RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; protein phosphatase 1, regulatory subunit 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047095.1 RefSeqGene

Range

23596..97969

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001252641.2 → NP_001239570.1 unconventional prefoldin RPB5 interactor 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has distinct N- and C-termini, compared to isoform a.

Source sequence(s)

AA678820, AW003989, AW954529, BC026184, BG742069

Consensus CDS

CCDS58658.1

UniProtKB/TrEMBL

Q6NX55

Related

ENSP00000353817.4, ENST00000360605.8

Conserved Domains (1) summary

cl09111
Location:27 → 129

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_003796.3 → NP_003787.2 unconventional prefoldin RPB5 interactor 1 isoform a

See identical proteins and their annotated locations for NP_003787.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AA678820, AK292170, AW003989, AW954529, BG742069, DB461036

Consensus CDS

CCDS12420.1

UniProtKB/Swiss-Prot

A8K805, H7BY42, O94763, Q8TC23, Q9UNU3

UniProtKB/TrEMBL

Q6NX55

Related

ENSP00000376097.2, ENST00000392271.6

Conserved Domains (1) summary

cl09111
Location:38 → 147

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RNA

NR_045557.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA678820, AW003989, AW954529, BC067259, BG742069, DB461036

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

29923657..30016612

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mRNA and Protein(s)

XM_005259362.3 → XP_005259419.1 unconventional prefoldin RPB5 interactor 1 isoform X1

UniProtKB/TrEMBL

Q6NX55

Conserved Domains (1) summary

cl09111
Location:27 → 129

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_047439595.1 → XP_047295551.1 unconventional prefoldin RPB5 interactor 1 isoform X4
XM_011527435.3 → XP_011525737.1 unconventional prefoldin RPB5 interactor 1 isoform X3

UniProtKB/TrEMBL

Q6NX55

Conserved Domains (1) summary

cl09111
Location:8 → 99

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_005259363.5 → XP_005259420.1 unconventional prefoldin RPB5 interactor 1 isoform X2

UniProtKB/TrEMBL

Q6NX55

Conserved Domains (1) summary

cl09111
Location:38 → 147

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_047439596.1 → XP_047295552.1 unconventional prefoldin RPB5 interactor 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

32444098..32537026

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322482.1 → XP_054178457.1 unconventional prefoldin RPB5 interactor 1 isoform X1
XM_054322485.1 → XP_054178460.1 unconventional prefoldin RPB5 interactor 1 isoform X4
XM_054322484.1 → XP_054178459.1 unconventional prefoldin RPB5 interactor 1 isoform X3
XM_054322483.1 → XP_054178458.1 unconventional prefoldin RPB5 interactor 1 isoform X2
XM_054322486.1 → XP_054178461.1 unconventional prefoldin RPB5 interactor 1 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_134447.1: Suppressed sequence

Description

NM_134447.1: This RefSeq was permanently suppressed because it has an inhibitory upstream ORF and there is no support for the protein.