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MPDZ multiple PDZ domain crumbs cell polarity complex component [ Homo sapiens (human) ]

Gene ID: 8777, updated on 3-Apr-2024

Summary

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Official Symbol
MPDZprovided by HGNC
Official Full Name
multiple PDZ domain crumbs cell polarity complex componentprovided by HGNC
Primary source
HGNC:HGNC:7208
See related
Ensembl:ENSG00000107186 MIM:603785; AllianceGenome:HGNC:7208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYC2; MUPP1
Summary
The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in liver (RPKM 12.7), fat (RPKM 10.5) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9p23
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (13105707..13279692, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (13115022..13289091, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (13105706..13279691, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 137 Neighboring gene peroxiredoxin 1 pseudogene 1 Neighboring gene lupus La protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13037568-13038084 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13251447-13252059 Neighboring gene Sharpr-MPRA regulatory region 14432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:13277167-13277882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13277883-13278598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13278599-13279314 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13369413-13369918 Neighboring gene long intergenic non-protein coding RNA 1235 Neighboring gene uncharacterized LOC105375977

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population. Hao XD, et al. Ophthalmic Genet, 2015 Jun. PMID 25675348
  2. The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex. Assémat E, et al. Exp Cell Res, 2013 Oct 15. PMID 23880463
  3. Mutation in MPDZ causes severe congenital hydrocephalus. Al-Dosari MS, et al. J Med Genet, 2013 Jan. PMID 23240096
  4. Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Karpyak VM, et al. Addict Biol, 2012 Jul. PMID 21762291, Free PMC Article
  5. Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population. Yuan S, et al. BMC Ophthalmol, 2022 Mar 19. PMID 35305607, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer.
    Title: MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer.
  2. Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review.
    Title: Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review.
  3. Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
    Title: Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
  4. ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.
    Title: ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.
  5. MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway.
    Title: MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway.
  6. Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
    Title: Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
  7. DAPLE and MPDZ function as cooperative partners at apical junctions.
    Title: DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction.
  8. Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling.
    Title: MPDZ promotes DLL4-induced Notch signaling during angiogenesis.
  9. This study confirmed the association of SNP rs1324183 in MPDZ-NF1B with keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention.
    Title: Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus.
  10. two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction.
    Title: Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hydrocephalus, nonsyndromic, autosomal recessive 2
MedGen: C3554691 OMIM: 615219 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of multiple PDZ domain protein (MPDZ) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25909, FLJ34626, FLJ90240, DKFZp781P216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multiple PDZ domain protein
Names
multi-PDZ domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042810.2 RefSeqGene

    Range
    5000..178985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261406.2 → NP_001248335.1  multiple PDZ domain protein isoform 2

    See identical proteins and their annotated locations for NP_001248335.1

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59120.1
    UniProtKB/TrEMBL
    F5H1U9
    Related
    ENSP00000415208.1, ENST00000447879.6
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  2. NM_001261407.2 → NP_001248336.1  multiple PDZ domain protein isoform 3

    See identical proteins and their annotated locations for NP_001248336.1

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59119.1
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  3. NM_001330637.2 → NP_001317566.1  multiple PDZ domain protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS83342.1
    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2; L27_2
    pfam16667
    Location:1562 → 1626
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  4. NM_001375413.1 → NP_001362342.1  multiple PDZ domain protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1595 → 1659
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  5. NM_001375416.1 → NP_001362345.1  multiple PDZ domain protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59120.1
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  6. NM_001375417.1 → NP_001362346.1  multiple PDZ domain protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59120.1
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  7. NM_001375418.1 → NP_001362347.1  multiple PDZ domain protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59120.1
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  8. NM_001375419.1 → NP_001362348.1  multiple PDZ domain protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS59119.1
    UniProtKB/TrEMBL
    F5H1U9
    Related
    ENSP00000444151.1, ENST00000536827.5
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1529 → 1593
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  9. NM_001375420.1 → NP_001362349.1  multiple PDZ domain protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1916 → 1999
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  10. NM_001375421.1 → NP_001362350.1  multiple PDZ domain protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1916 → 1999
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  11. NM_001375422.1 → NP_001362351.1  multiple PDZ domain protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1916 → 1999
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  12. NM_001375423.1 → NP_001362352.1  multiple PDZ domain protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1916 → 1999
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  13. NM_001375424.1 → NP_001362353.1  multiple PDZ domain protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1916 → 1999
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  14. NM_001375425.1 → NP_001362354.1  multiple PDZ domain protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1887 → 1970
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  15. NM_001375426.1 → NP_001362355.1  multiple PDZ domain protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1887 → 1970
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1492 → 1556
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  16. NM_001375427.1 → NP_001362356.1  multiple PDZ domain protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1850 → 1933
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1426 → 1490
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  17. NM_001378778.1 → NP_001365707.1  multiple PDZ domain protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS83342.1
    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
    UniProtKB/TrEMBL
    F5H1U9
    Related
    ENSP00000320006.7, ENST00000319217.12

  18. NM_003829.5 → NP_003820.2  multiple PDZ domain protein isoform 1

    See identical proteins and their annotated locations for NP_003820.2

    Status: REVIEWED

    Source sequence(s)
    AL161449, AL162386, AL353639, KF458902
    Consensus CDS
    CCDS47951.1
    UniProtKB/TrEMBL
    F5H1U9
    Related
    ENSP00000439807.1, ENST00000541718.5
    Conserved Domains (4) summary
    pfam09045
    Location:6 → 63
    L27_2; L27_2
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:1562 → 1626
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    13105707..13279692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424033.1 → XP_047279989.1  multiple PDZ domain protein isoform X5

  2. XM_017015252.2 → XP_016870741.1  multiple PDZ domain protein isoform X2

    UniProtKB/TrEMBL
    F5H1U9

  3. XM_006716888.4 → XP_006716951.1  multiple PDZ domain protein isoform X3

    See identical proteins and their annotated locations for XP_006716951.1

    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    pfam09045
    Location:6 → 63
    L27_2; L27_2
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:1562 → 1626
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  4. XM_047424044.1 → XP_047280000.1  multiple PDZ domain protein isoform X8

  5. XM_047424016.1 → XP_047279972.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  6. XM_047424035.1 → XP_047279991.1  multiple PDZ domain protein isoform X6

  7. XM_006716886.4 → XP_006716949.1  multiple PDZ domain protein isoform X1

    See identical proteins and their annotated locations for XP_006716949.1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2; L27_2
    pfam16667
    Location:1562 → 1626
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  8. XM_047424042.1 → XP_047279998.1  multiple PDZ domain protein isoform X8

  9. XM_047424025.1 → XP_047279981.1  multiple PDZ domain protein isoform X4

  10. XM_024447708.2 → XP_024303476.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
    UniProtKB/TrEMBL
    F5H1U9
    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2; L27_2
    pfam16667
    Location:1562 → 1626
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  11. XM_047424039.1 → XP_047279995.1  multiple PDZ domain protein isoform X8

  12. XM_047424028.1 → XP_047279984.1  multiple PDZ domain protein isoform X4

  13. XM_047424013.1 → XP_047279969.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  14. XM_047424045.1 → XP_047280001.1  multiple PDZ domain protein isoform X8

  15. XM_047424015.1 → XP_047279971.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  16. XM_047424043.1 → XP_047279999.1  multiple PDZ domain protein isoform X8

  17. XM_047424031.1 → XP_047279987.1  multiple PDZ domain protein isoform X4

  18. XM_047424046.1 → XP_047280002.1  multiple PDZ domain protein isoform X9

    Conserved Domains (4) summary
    smart00228
    Location:374 → 463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1149 → 1240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:6 → 63
    L27_2
    pfam16667
    Location:1595 → 1659
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

  19. XM_047424037.1 → XP_047279993.1  multiple PDZ domain protein isoform X8

  20. XM_047424034.1 → XP_047279990.1  multiple PDZ domain protein isoform X6

  21. XM_047424023.1 → XP_047279979.1  multiple PDZ domain protein isoform X4

  22. XM_047424009.1 → XP_047279965.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  23. XM_047424022.1 → XP_047279978.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  24. XM_054328427.1 → XP_054184402.1  multiple PDZ domain protein isoform X7

  25. XM_047424012.1 → XP_047279968.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  26. XM_047424036.1 → XP_047279992.1  multiple PDZ domain protein isoform X8

  27. XM_047424024.1 → XP_047279980.1  multiple PDZ domain protein isoform X4

  28. XM_047424010.1 → XP_047279966.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  29. XM_047424026.1 → XP_047279982.1  multiple PDZ domain protein isoform X4

  30. XM_047424014.1 → XP_047279970.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  31. XM_047424020.1 → XP_047279976.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  32. XM_047424019.1 → XP_047279975.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  33. XM_047424018.1 → XP_047279974.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  34. XM_047424038.1 → XP_047279994.1  multiple PDZ domain protein isoform X8

  35. XM_047424029.1 → XP_047279985.1  multiple PDZ domain protein isoform X4

  36. XM_047424017.1 → XP_047279973.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  37. XM_047424027.1 → XP_047279983.1  multiple PDZ domain protein isoform X4

  38. XM_047424041.1 → XP_047279997.1  multiple PDZ domain protein isoform X8

  39. XM_047424032.1 → XP_047279988.1  multiple PDZ domain protein isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    13115022..13289091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364122.1 → XP_054220097.1  multiple PDZ domain protein isoform X7

  2. XM_054364112.1 → XP_054220087.1  multiple PDZ domain protein isoform X4

  3. XM_054364100.1 → XP_054220075.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  4. XM_054364115.1 → XP_054220090.1  multiple PDZ domain protein isoform X4

  5. XM_054364098.1 → XP_054220073.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  6. XM_054364119.1 → XP_054220094.1  multiple PDZ domain protein isoform X5

  7. XM_054364108.1 → XP_054220083.1  multiple PDZ domain protein isoform X2

  8. XM_054364109.1 → XP_054220084.1  multiple PDZ domain protein isoform X3

  9. XM_054364131.1 → XP_054220106.1  multiple PDZ domain protein isoform X8

  10. XM_054364102.1 → XP_054220077.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  11. XM_054364121.1 → XP_054220096.1  multiple PDZ domain protein isoform X6

  12. XM_054364095.1 → XP_054220070.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  13. XM_054364129.1 → XP_054220104.1  multiple PDZ domain protein isoform X8

  14. XM_054364127.1 → XP_054220102.1  multiple PDZ domain protein isoform X8

  15. XM_054364132.1 → XP_054220107.1  multiple PDZ domain protein isoform X8

  16. XM_054364101.1 → XP_054220076.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  17. XM_054364130.1 → XP_054220105.1  multiple PDZ domain protein isoform X8

  18. XM_054364117.1 → XP_054220092.1  multiple PDZ domain protein isoform X4

  19. XM_054364125.1 → XP_054220100.1  multiple PDZ domain protein isoform X8

  20. XM_054364120.1 → XP_054220095.1  multiple PDZ domain protein isoform X6

  21. XM_054364110.1 → XP_054220085.1  multiple PDZ domain protein isoform X4

  22. XM_054364094.1 → XP_054220069.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  23. XM_054364107.1 → XP_054220082.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  24. XM_054364123.1 → XP_054220098.1  multiple PDZ domain protein isoform X7

  25. XM_054364097.1 → XP_054220072.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  26. XM_054364124.1 → XP_054220099.1  multiple PDZ domain protein isoform X8

  27. XM_054364111.1 → XP_054220086.1  multiple PDZ domain protein isoform X4

  28. XM_054364096.1 → XP_054220071.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  29. XM_054364113.1 → XP_054220088.1  multiple PDZ domain protein isoform X4

  30. XM_054364099.1 → XP_054220074.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  31. XM_054364106.1 → XP_054220081.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  32. XM_054364105.1 → XP_054220080.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  33. XM_054364104.1 → XP_054220079.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  34. XM_054364126.1 → XP_054220101.1  multiple PDZ domain protein isoform X8

  35. XM_054364116.1 → XP_054220091.1  multiple PDZ domain protein isoform X4

  36. XM_054364103.1 → XP_054220078.1  multiple PDZ domain protein isoform X1

    UniProtKB/Swiss-Prot
    A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

  37. XM_054364114.1 → XP_054220089.1  multiple PDZ domain protein isoform X4

  38. XM_054364133.1 → XP_054220108.1  multiple PDZ domain protein isoform X9

  39. XM_054364128.1 → XP_054220103.1  multiple PDZ domain protein isoform X8

  40. XM_054364118.1 → XP_054220093.1  multiple PDZ domain protein isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75970.2 GenPept UniProtKB/Swiss-Prot:O75970

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