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FGF17 fibroblast growth factor 17 [ Homo sapiens (human) ]

Gene ID: 8822, updated on 11-Apr-2024

Summary

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Official Symbol
FGF17provided by HGNC
Official Full Name
fibroblast growth factor 17provided by HGNC
Primary source
HGNC:HGNC:3673
See related
Ensembl:ENSG00000158815 MIM:603725; AllianceGenome:HGNC:3673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH20; FGF-13; FGF-17
Summary
This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See FGF17 in Genome Data Viewer
Location:
8p21.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22039672..22048809)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22313628..22322765)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21900264..21906320)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exportin 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21802075-21802708 Neighboring gene uncharacterized LOC124901903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21806752-21807252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27071 Neighboring gene VISTA enhancer hs783 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21867514-21868173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21868174-21868832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21880733-21881446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21881447-21882159 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21893938-21894622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21894623-21895307 Neighboring gene VISTA enhancer hs782 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene VISTA enhancer hs781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21908959-21909751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21915443-21916404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21917368-21918329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18975 Neighboring gene dematin actin binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21943692-21944301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21951526-21952026 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21961808-21961955 Neighboring gene FHF complex subunit HOOK interacting protein 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FGF17, a gene involved in cerebellar development, is downregulated in a patient with Dandy-Walker malformation carrying a de novo 8p deletion. Zanni G, et al. Neurogenetics, 2011 Aug. PMID 21484435
  2. FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia. Polnaszek N, et al. Prostate, 2004 Jun 15. PMID 15129425
  3. FGF10/FGF17 as prognostic and drug response markers in acute myeloid leukemia. Ling Y, et al. Curr Res Transl Med, 2022 Jan. PMID 34731724
  4. Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis. Gauglhofer C, et al. Hepatology, 2011 Mar. PMID 21319186
  5. Identification and characterization of a novel member of the fibroblast growth factor family. Greene JM, et al. Eur J Neurosci, 1998 May. PMID 9751161

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGF10/FGF17 as prognostic and drug response markers in acute myeloid leukemia.
    Title: FGF10/FGF17 as prognostic and drug response markers in acute myeloid leukemia.
  2. FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism.
    Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
  3. FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis.
    Title: Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis.
  4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
  5. FGF17 expression is increased 2-fold in benign prostatic hyperplasia and may contribute to the increased epithelial proliferation seen in this disease.
    Title: FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type 1 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 1 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 2 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033889.1 RefSeqGene

    Range
    4904..10893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001304478.1 → NP_001291407.1  fibroblast growth factor 17 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001291407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC091171, BM666883, DR159037
    Consensus CDS
    CCDS78310.1
    UniProtKB/Swiss-Prot
    O60258
    Related
    ENSP00000431041.1, ENST00000518533.5
    Conserved Domains (1) summary
    pfam00167
    Location:42 → 164
    FGF; Fibroblast growth factor

  2. NM_003867.4 → NP_003858.1  fibroblast growth factor 17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091171, BC105131, BM666883
    Consensus CDS
    CCDS6019.1
    UniProtKB/Swiss-Prot
    B7ZLG4, O60258, Q2M2W1
    Related
    ENSP00000352414.3, ENST00000359441.4
    Conserved Domains (1) summary
    pfam00167
    Location:53 → 175
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22039672..22048809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544683.2 → XP_011542985.1  fibroblast growth factor 17 isoform X2

    See identical proteins and their annotated locations for XP_011542985.1

    Conserved Domains (1) summary
    pfam00167
    Location:69 → 191
    FGF; Fibroblast growth factor

  2. XM_011544685.2 → XP_011542987.1  fibroblast growth factor 17 isoform X3

    Conserved Domains (1) summary
    pfam00167
    Location:58 → 180
    FGF; Fibroblast growth factor

  3. XM_011544684.2 → XP_011542986.1  fibroblast growth factor 17 isoform X2

    See identical proteins and their annotated locations for XP_011542986.1

    Conserved Domains (1) summary
    pfam00167
    Location:69 → 191
    FGF; Fibroblast growth factor

  4. XM_005273675.2 → XP_005273732.1  fibroblast growth factor 17 isoform X1

    See identical proteins and their annotated locations for XP_005273732.1

    UniProtKB/TrEMBL
    A0A7U3JVY9
    Related
    ENST00000524314.1
    Conserved Domains (1) summary
    pfam00167
    Location:76 → 198
    FGF; Fibroblast growth factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22313628..22322765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361441.1 → XP_054217416.1  fibroblast growth factor 17 isoform X2

  2. XM_054361443.1 → XP_054217418.1  fibroblast growth factor 17 isoform X3

  3. XM_054361442.1 → XP_054217417.1  fibroblast growth factor 17 isoform X2

  4. XM_054361440.1 → XP_054217415.1  fibroblast growth factor 17 isoform X1

    UniProtKB/TrEMBL
    A0A7U3JVY9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60258.1 GenPept UniProtKB/Swiss-Prot:O60258

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