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nirS nitrite reductase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882217, updated on 6-Oct-2023

Summary

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Gene symbol
nirS
Gene description
nitrite reductase
Locus tag
PA0519
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (578394..580100, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene heme d1 biosynthesis protein NirF Neighboring gene cytochrome c55X Neighboring gene cytochrome C-551 Neighboring gene denitrification regulatory protein NirQ Neighboring gene cytochrome C oxidase subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis. Scoffield JA, et al. Microbiology (Reading), 2016 Feb. PMID 26673783, Free PMC Article
  2. Fine-tuned regulation of the dissimilatory nitrite reductase gene by oxygen and nitric oxide in Pseudomonas aeruginosa. Kuroki M, et al. Environ Microbiol Rep, 2014 Dec. PMID 25186017
  3. Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase. Rinaldo S, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17904106
  4. Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF. Nicke T, et al. Biosci Rep, 2013 Jun 27. PMID 23683062, Free PMC Article
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the results suggest that nitrite reductase plays an important role for survival of P. aeruginosa during co-infection with S. parasanguinis.
    Title: Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis.
  2. NirS is transcribed under low oxygen conditions in an ANR-dependent manner.
    Title: Fine-tuned regulation of the dissimilatory nitrite reductase gene by oxygen and nitric oxide in Pseudomonas aeruginosa.
  3. NirS interacts with the potential haem d1 insertion protein NirN in vivo. This NirS-NirN interaction is dependent on the presence of the putative haem d1 biosynthesis enzyme NirF.
    Title: Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF.
  4. Results demonstrate that the the physiological substrate nitrite displaces NO from the ferrous enzyme.
    Title: Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables nitrite reductase (NO-forming) activity TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nitrite reductase
NP_249210.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    578394..580100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249210.1 nitrite reductase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249210.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G8A456
    Conserved Domains (2) summary
    COG2010
    Location:23 → 160
    CccA; Cytochrome c, mono- and diheme variants [Energy production and conversion]
    pfam02239
    Location:170 → 563
    Cytochrom_D1; Cytochrome D1 heme domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5GUW_M.1
5GUW_N.1
P24474.1

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