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pks13 polyketide synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886133, updated on 6-Oct-2023

Summary

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Gene symbol
pks13
Gene description
polyketide synthase
Locus tag
Rv3800c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4255945..4261146, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase FadE35 Neighboring gene insertion sequence element IS1557 transposase Neighboring gene propionyl-CoA carboxylase subunit beta AccD Neighboring gene long-chain-fatty-acid--AMP ligase FadD32 Neighboring gene membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
    Title: Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
  2. Insights into structures of imidazo oxazines as potent polyketide synthase XIII inhibitors using molecular modeling techniques.
    Title: Insights into structures of imidazo oxazines as potent polyketide synthase XIII inhibitors using molecular modeling techniques.
  3. M. tuberculosis Pks13 is required for mycolic acid biosynthesis
    Title: Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
  4. Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13
    Title: Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
  5. Data show that the couple FadD32-(N-ACP(Pks13)) composes the initiation module of the mycolic condensation system.
    Title: The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
polyketide synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4255945..4261146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218317.1 polyketide synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218317.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M878
    Conserved Domains (5) summary
    smart00823
    Location:16 → 93
    PKS_PP; Phosphopantetheine attachment site
    COG3319
    Location:1470 → 1727
    EntF; Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism]
    COG3321
    Location:119 → 1258
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    PRK12467
    Location:1283 → 1571
    PRK12467; peptide synthase; Provisional
    pfam00550
    Location:1241 → 1287
    PP-binding; Phosphopantetheine attachment site
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
I6X8D2.1

Gene LinkOut

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Molecular Biology Databases
Research Materials