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SERPINB11 serpin family B member 11 [ Homo sapiens (human) ]

Gene ID: 89778, updated on 3-Apr-2024

Summary

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Official Symbol
SERPINB11provided by HGNC
Official Full Name
serpin family B member 11provided by HGNC
Primary source
HGNC:HGNC:14221
See related
Ensembl:ENSG00000206072 MIM:615682; AllianceGenome:HGNC:14221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPIPIN; SERPIN11
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in prostate (RPKM 17.6), esophagus (RPKM 11.7) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See SERPINB11 in Genome Data Viewer
Location:
18q21.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63702304..63723893)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (63907377..63928969)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61369538..61391127)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:61308020-61309219 Neighboring gene serpin family B member 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:61326051-61327250 Neighboring gene serpin family B member 3 Neighboring gene uncharacterized LOC124904318 Neighboring gene serpin family B member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions. Seixas S, et al. PLoS One, 2012. PMID 22393410, Free PMC Article
  2. Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens. Lim W, et al. Exp Biol Med (Maywood), 2012 Feb. PMID 22289513
  3. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. Askew DJ, et al. J Biol Chem, 2007 Aug 24. PMID 17562709
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article
  5. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SERPINB11 is a gene under selection on standing variation, with roles in host-pathogen interactions
    Title: Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions.
  2. SERPINB11 has a role in ovarian endometrioid carcinoma in chickens and human
    Title: Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens.
  3. SERPINB11 is a new noninhibitory intracellular serpin
    Title: SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC163242, MGC163244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serpin B11
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11
serpin peptidase inhibitor, clade B (ovalbumin), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291278.2 → NP_001278207.1  serpin B11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    Consensus CDS
    CCDS77196.1
    UniProtKB/TrEMBL
    A0A096LPD5
    Related
    ENSP00000485532.1, ENST00000623262.3
    Conserved Domains (1) summary
    cl00137
    Location:4 → 305
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_001291279.2 → NP_001278208.1  serpin B11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    UniProtKB/TrEMBL
    B4DKT7
    Conserved Domains (1) summary
    cl00137
    Location:1 → 217
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  3. NM_001370475.1 → NP_001357404.1  serpin B11 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    UniProtKB/Swiss-Prot
    A8K9R0, Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14, Q96P15
    UniProtKB/TrEMBL
    A9UKE9, F5GYW9
    Related
    ENSP00000441497.1, ENST00000544088.6
    Conserved Domains (1) summary
    cd02059
    Location:4 → 392
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

  4. NM_001426565.1 → NP_001413494.1  serpin B11 isoform d

    Status: VALIDATED

    Source sequence(s)
    CP068260

  5. NM_001426567.1 → NP_001413496.1  serpin B11 isoform e

    Status: VALIDATED

    Source sequence(s)
    CP068260

  6. NM_080475.5 → NP_536723.2  serpin B11 isoform a

    See identical proteins and their annotated locations for NP_536723.2

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    UniProtKB/Swiss-Prot
    A8K9R0, Q5Q120, Q5Q121, Q5Q122, Q5Q123, Q6ISD3, Q96P13, Q96P14, Q96P15
    UniProtKB/TrEMBL
    A9UKE9, F5GYW9
    Related
    ENSP00000421854.1, ENST00000382749.9
    Conserved Domains (1) summary
    cd02059
    Location:4 → 392
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    63702304..63723893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    63907377..63928969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96P15.2 GenPept UniProtKB/Swiss-Prot:Q96P15

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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