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Bud31 BUD31 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 89819, updated on 13-Apr-2024

Summary

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Official Symbol
Bud31provided by RGD
Official Full Name
BUD31 homologprovided by RGD
Primary source
RGD:621103
See related
Ensembl:ENSRNOG00000000989 AllianceGenome:RGD:621103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G10; Edg2; LPA1
Summary
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of androgen receptor activity. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to colocalize with chromatin. Biomarker of schistosomiasis. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 375.6), Thymus (RPKM 370.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bud31 in Genome Data Viewer
Location:
12p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14576602..14584132, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9462838..9470387, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11232963..11240449, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene ATP synthase membrane subunit f Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene PDGFA associated protein 1 Neighboring gene actin related protein 2/3 complex, subunit 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and profiling of circulating antigens by screening with the sera from schistosomiasis japonica patients. Lu Y, et al. Parasit Vectors, 2012 Jun 11. PMID 22686541, Free PMC Article
  2. The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Hirata T, et al. Brain Res, 2007 Jan 26. PMID 17173873
  3. EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Savitz SI, et al. Brain Res, 2006 Nov 6. PMID 17026968
  4. Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. Sautin YY, et al. J Hematother Stem Cell Res, 2002 Aug. PMID 12201952
  5. Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid. Stankoff B, et al. Mol Cell Neurosci, 2002 Jul. PMID 12139919

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein BUD31 homolog
Names
EDG-2
maternal G10 transcript
protein EDG-2
protein G10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053556.2 → NP_446008.2  protein BUD31 homolog

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Related
    ENSRNOP00000001307.4, ENSRNOT00000001307.8
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    14576602..14584132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248889.4 → XP_006248951.1  protein BUD31 homolog isoform X1

    See identical proteins and their annotated locations for XP_006248951.1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  2. XM_006248887.4 → XP_006248949.1  protein BUD31 homolog isoform X1

    See identical proteins and their annotated locations for XP_006248949.1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  3. XM_039089844.2 → XP_038945772.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  4. XM_063271721.1 → XP_063127791.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5

  5. XM_063271724.1 → XP_063127794.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5

  6. XM_039089845.2 → XP_038945773.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  7. XM_039089846.2 → XP_038945774.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  8. XM_063271723.1 → XP_063127793.1  protein BUD31 homolog isoform X1

    UniProtKB/Swiss-Prot
    O70454, Q6PDW3
    UniProtKB/TrEMBL
    A6K1F5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70454.2 GenPept UniProtKB/Swiss-Prot:O70454

Gene LinkOut

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