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Pcyt2 phosphate cytidylyltransferase 2, ethanolamine [ Rattus norvegicus (Norway rat) ]

Gene ID: 89841, updated on 30-Mar-2024

Summary

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Official Symbol
Pcyt2provided by RGD
Official Full Name
phosphate cytidylyltransferase 2, ethanolamineprovided by RGD
Primary source
RGD:619970
See related
Ensembl:ENSRNOG00000036684 AllianceGenome:RGD:619970
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ET
Summary
Enables ethanolamine-phosphate cytidylyltransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 637.3), Kidney (RPKM 196.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106387150..106394500, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105888769..105896182, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109788348..109795743, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B Neighboring gene sirtuin 7 Neighboring gene MAF bZIP transcription factor G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. Bleijerveld OB, et al. Biochem J, 2004 May 1. PMID 14759225, Free PMC Article
  2. Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver. Bladergroen BA, et al. Biochem J, 1999 Oct 1. PMID 10493918, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. supply of CDPethanolamine, via the expression level of ECT, is an important factor governing the rate of PtdEtn biosynthesis in mammalian cells, under the condition that the amount of DAG is not limiting
    Title: Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93299

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ethanolamine-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ethanolamine-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine-phosphate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ethanolamine-phosphate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ethanolamine-phosphate cytidylyltransferase
Names
CTP:phopshoethanolamine cytidylyltransferase
CTP:phosphoethanolamine cytidylyltransferase
phosphorylethanolamine transferase
NP_446020.1
XP_006247997.1
XP_038942930.1
XP_038942932.1
XP_038942933.1
XP_063126073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053568.2 → NP_446020.1  ethanolamine-phosphate cytidylyltransferase

    See identical proteins and their annotated locations for NP_446020.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O88637, Q6AZ30
    UniProtKB/TrEMBL
    A0A8I6AET7, A6HLG4
    Related
    ENSRNOP00000090700.1, ENSRNOT00000111239.1
    Conserved Domains (1) summary
    PTZ00308
    Location:22 → 390
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106387150..106394500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247935.5 → XP_006247997.1  ethanolamine-phosphate cytidylyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006247997.1

    UniProtKB/TrEMBL
    A0A8L2QPS4, A6HLG3
    Related
    ENSRNOP00000051835.3
    Conserved Domains (1) summary
    PTZ00308
    Location:22 → 372
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

  2. XM_063270003.1 → XP_063126073.1  ethanolamine-phosphate cytidylyltransferase isoform X3

  3. XM_039087002.2 → XP_038942930.1  ethanolamine-phosphate cytidylyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZT93, A0A8I6AET7
    Related
    ENSRNOP00000082255.1
    Conserved Domains (1) summary
    PTZ00308
    Location:2 → 371
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

  4. XM_039087004.2 → XP_038942932.1  ethanolamine-phosphate cytidylyltransferase isoform X4

    Conserved Domains (1) summary
    cd02173
    Location:34 → 186
    ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)

  5. XM_039087005.2 → XP_038942933.1  ethanolamine-phosphate cytidylyltransferase isoform X5

    UniProtKB/TrEMBL
    A0A8I6AET7
    Conserved Domains (1) summary
    PTZ00308
    Location:22 → 345
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

RNA

  1. XR_005489961.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88637.1 GenPept UniProtKB/Swiss-Prot:O88637

Gene LinkOut

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