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TPD52L3 TPD52 like 3 [ Homo sapiens (human) ]

Gene ID: 89882, updated on 3-Apr-2024

Summary

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Official Symbol
TPD52L3provided by HGNC
Official Full Name
TPD52 like 3provided by HGNC
Primary source
HGNC:HGNC:23382
See related
Ensembl:ENSG00000170777 MIM:617567; AllianceGenome:HGNC:23382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D55; hD55; TPD55; NYDSP25
Summary
This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward testis (RPKM 52.1) See more
Orthologs
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Genomic context

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Location:
9p24.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (6328375..6331891)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (6333439..6336954)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6328375..6331891)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19763 Neighboring gene interleukin 33 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28186 Neighboring gene ubiquitin like with PHD and ring finger domains 2 Neighboring gene RNA, 7SL, cytoplasmic 25, pseudogene Neighboring gene glycine decarboxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. Cao Q, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631610
  2. The SARS-CoV-2 spike protein binds and modulates estrogen receptors. Solis O, et al. Sci Adv, 2022 Dec 2. PMID 36449624, Free PMC Article
  3. Genome-wide association study of periodontal pathogen colonization. Divaris K, et al. J Dent Res, 2012 Jul. PMID 22699663, Free PMC Article
  4. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26757, MGC45374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor protein D55
Names
protein kinase NYD-SP25
testis development protein NYD-SP25
testis tissue sperm-binding protein Li 87P
tumor protein D52 like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001874.3 → NP_001001874.2  tumor protein D55 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34984.1
    UniProtKB/TrEMBL
    A0A140VKH0
    Related
    ENSP00000318665.3, ENST00000314556.4
    Conserved Domains (1) summary
    pfam04201
    Location:6 → 127
    TPD52; tumor protein D52 family

  2. NM_001001875.4 → NP_001001875.2  tumor protein D55 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34985.1
    UniProtKB/TrEMBL
    A0A140VKH0
    Related
    ENSP00000370836.1, ENST00000381428.1
    Conserved Domains (1) summary
    pfam04201
    Location:6 → 123
    TPD52; tumor protein D52 family

  3. NM_033516.6 → NP_277051.4  tumor protein D55 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34986.1
    UniProtKB/Swiss-Prot
    Q5TCR3, Q5TCR4, Q5TCR5, Q8N4P5, Q8WWF7, Q96J77, Q96M09
    UniProtKB/TrEMBL
    A0A140VKH0
    Related
    ENSP00000341677.5, ENST00000344545.6
    Conserved Domains (1) summary
    pfam04201
    Location:6 → 136
    TPD52; tumor protein D52 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    6328375..6331891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015280.3 → XP_016870769.1  tumor protein D55 isoform X1

    UniProtKB/TrEMBL
    A0A140VKH0
    Conserved Domains (1) summary
    pfam04201
    Location:6 → 123
    TPD52; tumor protein D52 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    6333439..6336954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364142.1 → XP_054220117.1  tumor protein D55 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96J77.2 GenPept UniProtKB/Swiss-Prot:Q96J77

Gene LinkOut

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