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TAAR5 trace amine associated receptor 5 [ Homo sapiens (human) ]

Gene ID: 9038, updated on 5-Mar-2024

Summary

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Official Symbol
TAAR5provided by HGNC
Official Full Name
trace amine associated receptor 5provided by HGNC
Primary source
HGNC:HGNC:30236
See related
Ensembl:ENSG00000135569 MIM:607405; AllianceGenome:HGNC:30236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNR; taR-5
Summary
Enables trimethylamine receptor activity. Predicted to be involved in signal transduction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
6q23.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132588592..132616747, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133783556..133811705, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132909731..132937886, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 7, pseudogene Neighboring gene trace amine associated receptor 6 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene Neighboring gene trace amine associated receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17552 Neighboring gene trace amine associated receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. Vaganova AN, et al. Int J Mol Sci, 2021 Aug 16. PMID 34445502, Free PMC Article
  2. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming. Gisladottir RS, et al. Curr Biol, 2020 Dec 7. PMID 33035477
  3. Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5. Dinter J, et al. PLoS One, 2015. PMID 25706283, Free PMC Article
  4. Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. Zeng Z, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464258
  5. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. Wallrabenstein I, et al. PLoS One, 2013. PMID 23393561, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis.
    Title: Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis.
  2. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming.
    Title: Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming.
  3. The murine and human TAAR5 (hTAAR5) display significant basal activity in the Gq/11 pathway.
    Title: Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
  4. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
    Title: Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
  5. Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
    Title: A second class of chemosensory receptors in the olfactory epithelium.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC138414, MGC138416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables trace-amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables trimethylamine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trace amine-associated receptor 5
Names
putative neurotransmitter receptor
trace amine receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389527.1 → NP_001376456.1  trace amine-associated receptor 5

    Status: VALIDATED

    Source sequence(s)
    AL513524
    Consensus CDS
    CCDS5156.1
    UniProtKB/Swiss-Prot
    D8KZS1, O14804, Q2M1V1, Q4VBL1, Q5VUQ3, Q6NTA8
    Conserved Domains (1) summary
    cd15318
    Location:35 → 316
    7tmA_TAAR5; trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_003967.3 → NP_003958.2  trace amine-associated receptor 5

    See identical proteins and their annotated locations for NP_003958.2

    Status: VALIDATED

    Source sequence(s)
    AL513524
    Consensus CDS
    CCDS5156.1
    UniProtKB/Swiss-Prot
    D8KZS1, O14804, Q2M1V1, Q4VBL1, Q5VUQ3, Q6NTA8
    Related
    ENSP00000258034.2, ENST00000258034.4
    Conserved Domains (1) summary
    cd15318
    Location:35 → 316
    7tmA_TAAR5; trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132588592..132616747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133783556..133811705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14804.2 GenPept UniProtKB/Swiss-Prot:O14804

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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