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SHF Src homology 2 domain containing F [ Homo sapiens (human) ]

Gene ID: 90525, updated on 5-Mar-2024

Summary

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Official Symbol
SHFprovided by HGNC
Official Full Name
Src homology 2 domain containing Fprovided by HGNC
Primary source
HGNC:HGNC:25116
See related
Ensembl:ENSG00000138606 MIM:617313; AllianceGenome:HGNC:25116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 4.2), ovary (RPKM 4.0) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
15q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (45167214..45201116, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42975223..43009099, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45459412..45493314, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9349 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene uncharacterized LOC124903480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45459911-45460412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45461170-45461772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45461773-45462375 Neighboring gene uncharacterized LOC124903481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45471346-45471852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45475299-45475847 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45478592-45479144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6403 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:45493041-45493550 Neighboring gene tRNA-His (anticodon GTG) 1-7 Neighboring gene tRNA-His (anticodon GTG) 1-8 Neighboring gene tRNA-His (anticodon GTG) 1-9 Neighboring gene small nucleolar RNA SNORA11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization. Wang J, et al. Adv Sci (Weinh), 2022 Sep. PMID 35843865, Free PMC Article
  2. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. Takagi D, et al. Cancer Sci, 2013 May. PMID 23360421, Free PMC Article
  3. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Lindholm CK, et al. Biochem Biophys Res Commun, 2000 Nov 30. PMID 11095946
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number.
    Title: SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number.
  2. SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization.
    Title: SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization.
  3. Patients showing high ALK and low Shf mRNA expressions showed poor prognosis.
    Title: Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126650, MGC126652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH2 domain-containing adapter protein F
Names
CTD-2651B20.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301168.2 → NP_001288097.2  SH2 domain-containing adapter protein F isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    cd10392
    Location:339 → 436
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  2. NM_001301169.2 → NP_001288098.2  SH2 domain-containing adapter protein F isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76750.1
    UniProtKB/TrEMBL
    H0YLW6
    Related
    ENSP00000453370.1, ENST00000560540.5

  3. NM_001301170.2 → NP_001288099.2  SH2 domain-containing adapter protein F isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76749.1
    UniProtKB/TrEMBL
    H0YLD8
    Related
    ENSP00000453168.1, ENST00000560734.5

  4. NM_001301171.2 → NP_001288100.2  SH2 domain-containing adapter protein F isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS73721.1
    UniProtKB/TrEMBL
    B4DWP8, F8W6V4
    Related
    ENSP00000411530.2, ENST00000458022.6
    Conserved Domains (1) summary
    cd10392
    Location:137 → 234
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  5. NM_001394037.1 → NP_001380966.1  SH2 domain-containing adapter protein F isoform f

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS91993.1
    UniProtKB/TrEMBL
    A0A8I5QJ71
    Related
    ENSP00000508579.1, ENST00000690270.1
    Conserved Domains (1) summary
    cd10392
    Location:386 → 483
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  6. NM_001394038.1 → NP_001380967.1  SH2 domain-containing adapter protein F isoform g

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS91994.1
    UniProtKB/TrEMBL
    H0YLM1
    Related
    ENSP00000453260.1, ENST00000560471.5

  7. NM_001394039.1 → NP_001380968.1  SH2 domain-containing adapter protein F isoform h

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    cd10392
    Location:309 → 404
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

  8. NM_001394040.1 → NP_001380969.1  SH2 domain-containing adapter protein F isoform i

    Status: VALIDATED

    Source sequence(s)
    AC051619

  9. NM_001394041.1 → NP_001380970.1  SH2 domain-containing adapter protein F isoform j

    Status: VALIDATED

    Source sequence(s)
    AC051619
    UniProtKB/TrEMBL
    B3KTY1
    Conserved Domains (1) summary
    PHA03247
    Location:145 → 345
    PHA03247; large tegument protein UL36; Provisional

  10. NM_001394042.1 → NP_001380971.1  SH2 domain-containing adapter protein F isoform k

    Status: VALIDATED

    Source sequence(s)
    AC051619

  11. NM_001394043.1 → NP_001380972.1  SH2 domain-containing adapter protein F isoform l

    Status: VALIDATED

    Source sequence(s)
    AC051619

  12. NM_001394044.1 → NP_001380973.1  SH2 domain-containing adapter protein F isoform m

    Status: VALIDATED

    Source sequence(s)
    AC051619

  13. NM_001394045.1 → NP_001380974.1  SH2 domain-containing adapter protein F isoform n

    Status: VALIDATED

    Source sequence(s)
    AC051619

  14. NM_001394046.1 → NP_001380975.1  SH2 domain-containing adapter protein F isoform o

    Status: VALIDATED

    Source sequence(s)
    AC051619

  15. NM_001394047.1 → NP_001380976.1  SH2 domain-containing adapter protein F isoform p

    Status: VALIDATED

    Source sequence(s)
    AC051619

  16. NM_001394048.1 → NP_001380977.1  SH2 domain-containing adapter protein F isoform q

    Status: VALIDATED

    Source sequence(s)
    AC051619

  17. NM_138356.3 → NP_612365.3  SH2 domain-containing adapter protein F isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS10120.2
    UniProtKB/Swiss-Prot
    Q7M4L6, Q96IE8
    Related
    ENSP00000290894.8, ENST00000290894.12
    Conserved Domains (2) summary
    cd10392
    Location:321 → 418
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
    PHA03247
    Location:145 → 317
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    45167214..45201116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433286.1 → XP_047289242.1  SH2 domain-containing adapter protein F isoform X3

  2. XM_047433285.1 → XP_047289241.1  SH2 domain-containing adapter protein F isoform X2

  3. XM_017022710.2 → XP_016878199.1  SH2 domain-containing adapter protein F isoform X4

  4. XM_011522178.3 → XP_011520480.1  SH2 domain-containing adapter protein F isoform X5

  5. XM_047433284.1 → XP_047289240.1  SH2 domain-containing adapter protein F isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    42975223..43009099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379125.1 → XP_054235100.1  SH2 domain-containing adapter protein F isoform X3

  2. XM_054379124.1 → XP_054235099.1  SH2 domain-containing adapter protein F isoform X2

  3. XM_054379126.1 → XP_054235101.1  SH2 domain-containing adapter protein F isoform X4

  4. XM_054379127.1 → XP_054235102.1  SH2 domain-containing adapter protein F isoform X5

  5. XM_054379123.1 → XP_054235098.1  SH2 domain-containing adapter protein F isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M4L6.2 GenPept UniProtKB/Swiss-Prot:Q7M4L6

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