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MAP7 microtubule associated protein 7 [ Homo sapiens (human) ]

Gene ID: 9053, updated on 23-Nov-2021

Summary

Official Symbol
MAP7provided by HGNC
Official Full Name
microtubule associated protein 7provided by HGNC
Primary source
HGNC:HGNC:6869
See related
Ensembl:ENSG00000135525 MIM:604108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMAP115; E-MAP-115
Summary
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Expression
Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues See more
Orthologs
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Genomic context

See MAP7 in Genome Data Viewer
Location:
6q23.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (136342734..136550422, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (136663419..136871560, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 2 Neighboring gene BCL2 associated transcription factor 1 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 8 Neighboring gene phosphopantothenate--cysteine ligase pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 1 Neighboring gene RN7SK pseudogene 299 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene MAP3K5 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 219 Neighboring gene uncharacterized LOC101928429 Neighboring gene Sharpr-MPRA regulatory region 14394

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to osmotic stress ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ensconsin
Names
dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))
epithelial microtubule-associated protein of 115 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198608.3NP_001185537.1  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_001185537.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS56455.1
    UniProtKB/Swiss-Prot
    Q14244
    Conserved Domains (1) summary
    pfam05672
    Location:483641
    MAP7; MAP7 (E-MAP-115) family
  2. NM_001198609.2NP_001185538.1  ensconsin isoform 2

    See identical proteins and their annotated locations for NP_001185538.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS75527.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    A0A087WZ40, B7Z3E1
    Related
    ENSP00000482335.1, ENST00000617204.4
    Conserved Domains (2) summary
    PTZ00108
    Location:101317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:491649
    MAP7; MAP7 (E-MAP-115) family
  3. NM_001198611.3NP_001185540.1  ensconsin isoform 4

    See identical proteins and their annotated locations for NP_001185540.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS56454.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000400790.2, ENST00000438100.6
    Conserved Domains (3) summary
    PTZ00108
    Location:127406
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam17380
    Location:87173
    DUF5401; Family of unknown function (DUF5401)
    pfam05672
    Location:446604
    MAP7; MAP7 (E-MAP-115) family
  4. NM_001198614.2NP_001185543.1  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_001185543.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS56455.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    B7ZB64
    Related
    ENSP00000414712.1, ENST00000454590.5
    Conserved Domains (1) summary
    pfam05672
    Location:483641
    MAP7; MAP7 (E-MAP-115) family
  5. NM_001198615.3NP_001185544.1  ensconsin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL023284
    Consensus CDS
    CCDS56453.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000445737.1, ENST00000544465.5
    Conserved Domains (2) summary
    pfam05672
    Location:448604
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
  6. NM_001198616.3NP_001185545.1  ensconsin isoform 6

    See identical proteins and their annotated locations for NP_001185545.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Consensus CDS
    CCDS75529.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000482356.1, ENST00000618822.4
    Conserved Domains (2) summary
    pfam05672
    Location:426582
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2
  7. NM_001198617.3NP_001185546.1  ensconsin isoform 7

    See identical proteins and their annotated locations for NP_001185546.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Consensus CDS
    CCDS75528.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000483511.1, ENST00000616617.4
    Conserved Domains (1) summary
    pfam05672
    Location:369525
    MAP7; MAP7 (E-MAP-115) family
  8. NM_001198618.2NP_001185547.1  ensconsin isoform 8

    See identical proteins and their annotated locations for NP_001185547.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS56452.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    B7Z3Y3
    Related
    ENSP00000414879.2, ENST00000432797.6
    Conserved Domains (1) summary
    pfam05672
    Location:315473
    MAP7; MAP7 (E-MAP-115) family
  9. NM_001198619.2NP_001185548.1  ensconsin isoform 8

    See identical proteins and their annotated locations for NP_001185548.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Consensus CDS
    CCDS56452.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000482998.1, ENST00000611373.1
    Conserved Domains (1) summary
    pfam05672
    Location:315473
    MAP7; MAP7 (E-MAP-115) family
  10. NM_001388328.1NP_001375257.1  ensconsin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:101317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:491649
    MAP7; MAP7 (E-MAP-115) family
  11. NM_001388329.1NP_001375258.1  ensconsin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:101317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:491649
    MAP7; MAP7 (E-MAP-115) family
  12. NM_001388330.1NP_001375259.1  ensconsin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:101317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:491649
    MAP7; MAP7 (E-MAP-115) family
  13. NM_001388331.1NP_001375260.1  ensconsin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:490648
    MAP7; MAP7 (E-MAP-115) family
  14. NM_001388332.1NP_001375261.1  ensconsin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:483641
    MAP7; MAP7 (E-MAP-115) family
  15. NM_001388333.1NP_001375262.1  ensconsin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:483641
    MAP7; MAP7 (E-MAP-115) family
  16. NM_001388334.1NP_001375263.1  ensconsin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (2) summary
    PTZ00108
    Location:79295
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:469627
    MAP7; MAP7 (E-MAP-115) family
  17. NM_001388335.1NP_001375264.1  ensconsin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (1) summary
    pfam05672
    Location:468626
    MAP7; MAP7 (E-MAP-115) family
  18. NM_001388336.1NP_001375265.1  ensconsin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:127414
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:454612
    MAP7; MAP7 (E-MAP-115) family
  19. NM_001388337.1NP_001375266.1  ensconsin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:127414
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:454612
    MAP7; MAP7 (E-MAP-115) family
  20. NM_001388338.1NP_001375267.1  ensconsin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:127414
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:454612
    MAP7; MAP7 (E-MAP-115) family
  21. NM_001388339.1NP_001375268.1  ensconsin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (2) summary
    PTZ00108
    Location:105384
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:424605
    MAP7; MAP7 (E-MAP-115) family
  22. NM_001388340.1NP_001375269.1  ensconsin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (3) summary
    PTZ00108
    Location:127406
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam17380
    Location:87173
    DUF5401; Family of unknown function (DUF5401)
    pfam05672
    Location:446604
    MAP7; MAP7 (E-MAP-115) family
  23. NM_001388341.1NP_001375270.1  ensconsin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (3) summary
    PTZ00108
    Location:127406
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam17380
    Location:87173
    DUF5401; Family of unknown function (DUF5401)
    pfam05672
    Location:446604
    MAP7; MAP7 (E-MAP-115) family
  24. NM_001388342.1NP_001375271.1  ensconsin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (2) summary
    PTZ00108
    Location:105392
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:432590
    MAP7; MAP7 (E-MAP-115) family
  25. NM_001388343.1NP_001375272.1  ensconsin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    pfam17380
    Location:8122
    DUF5401; Family of unknown function (DUF5401)
    pfam05672
    Location:424582
    MAP7; MAP7 (E-MAP-115) family
  26. NM_001388344.1NP_001375273.1  ensconsin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (2) summary
    PTZ00108
    Location:101363
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam05672
    Location:403561
    MAP7; MAP7 (E-MAP-115) family
  27. NM_001388345.1NP_001375274.1  ensconsin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:352510
    MAP7; MAP7 (E-MAP-115) family
  28. NM_001388346.1NP_001375275.1  ensconsin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:352510
    MAP7; MAP7 (E-MAP-115) family
  29. NM_001388347.1NP_001375276.1  ensconsin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (1) summary
    pfam05672
    Location:330488
    MAP7; MAP7 (E-MAP-115) family
  30. NM_001388348.1NP_001375277.1  ensconsin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:315473
    MAP7; MAP7 (E-MAP-115) family
  31. NM_001388349.1NP_001375278.1  ensconsin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:315473
    MAP7; MAP7 (E-MAP-115) family
  32. NM_001388350.1NP_001375279.1  ensconsin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:278436
    MAP7; MAP7 (E-MAP-115) family
  33. NM_001388351.1NP_001375280.1  ensconsin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:278436
    MAP7; MAP7 (E-MAP-115) family
  34. NM_001388352.1NP_001375281.1  ensconsin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Conserved Domains (1) summary
    pfam05672
    Location:233391
    MAP7; MAP7 (E-MAP-115) family
  35. NM_001388353.1NP_001375282.1  ensconsin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL133511
    Conserved Domains (1) summary
    pfam05672
    Location:330366
    MAP7; MAP7 (E-MAP-115) family
  36. NM_003980.6NP_003971.1  ensconsin isoform 3

    See identical proteins and their annotated locations for NP_003971.1

    Status: REVIEWED

    Source sequence(s)
    AL023284, AL024508
    Consensus CDS
    CCDS5178.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000346581.2, ENST00000354570.8
    Conserved Domains (2) summary
    pfam05672
    Location:463619
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    136342734..136550422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536246.2XP_011534548.1  ensconsin isoform X8

    Conserved Domains (2) summary
    pfam05672
    Location:419575
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
  2. XM_011536243.2XP_011534545.1  ensconsin isoform X4

    Conserved Domains (2) summary
    pfam05672
    Location:456612
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
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