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ZNF502 zinc finger protein 502 [ Homo sapiens (human) ]

Gene ID: 91392, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF502provided by HGNC
Official Full Name
zinc finger protein 502provided by HGNC
Primary source
HGNC:HGNC:23718
See related
Ensembl:ENSG00000196653 AllianceGenome:HGNC:23718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.5), prostate (RPKM 2.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
3p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44712660..44723831)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44728342..44739513)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44754152..44765323)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44744951-44745158 Neighboring gene uncharacterized LOC105377056 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:44761628-44762827 Neighboring gene suppressor of cytokine signaling 5 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19770 Neighboring gene zinc finger protein 501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene KIAA1143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Kipper S, et al. Mol Cell Proteomics, 2015 Mar. PMID 25556234, Free PMC Article
  2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ENAH-202 promotes cancer progression in oral squamous cell carcinoma by regulating ZNF502/VIM axis.
    Title: ENAH-202 promotes cancer progression in oral squamous cell carcinoma by regulating ZNF502/VIM axis.
  2. Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus.
    Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12515, FLJ14855

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation by host of viral process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in viral release from host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 502

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134440.2 → NP_001127912.1  zinc finger protein 502

    See identical proteins and their annotated locations for NP_001127912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC098649, AC124045
    Consensus CDS
    CCDS2719.1
    UniProtKB/Swiss-Prot
    Q8TBZ5
    Conserved Domains (2) summary
    COG5048
    Location:151 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001134441.2 → NP_001127913.1  zinc finger protein 502

    See identical proteins and their annotated locations for NP_001127913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC098649, AC124045
    Consensus CDS
    CCDS2719.1
    UniProtKB/Swiss-Prot
    Q8TBZ5
    Related
    ENSP00000397390.1, ENST00000449836.5
    Conserved Domains (2) summary
    COG5048
    Location:151 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001134442.3 → NP_001127914.1  zinc finger protein 502

    See identical proteins and their annotated locations for NP_001127914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC098649, AC124045
    Consensus CDS
    CCDS2719.1
    UniProtKB/Swiss-Prot
    Q8TBZ5
    Related
    ENSP00000406469.2, ENST00000436624.7
    Conserved Domains (2) summary
    COG5048
    Location:151 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001282880.2 → NP_001269809.1  zinc finger protein 502

    See identical proteins and their annotated locations for NP_001269809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC098649, AC124045
    Consensus CDS
    CCDS2719.1
    UniProtKB/Swiss-Prot
    Q8TBZ5
    Conserved Domains (2) summary
    COG5048
    Location:151 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_033210.5 → NP_149987.2  zinc finger protein 502

    See identical proteins and their annotated locations for NP_149987.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC098649, AC124045
    Consensus CDS
    CCDS2719.1
    UniProtKB/Swiss-Prot
    Q8TBZ5
    Related
    ENSP00000296091.4, ENST00000296091.8
    Conserved Domains (2) summary
    COG5048
    Location:151 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44712660..44723831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    238010..249181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44728342..44739513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBZ5.1 GenPept UniProtKB/Swiss-Prot:Q8TBZ5

Gene LinkOut

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