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ZW10 zw10 kinetochore protein [ Homo sapiens (human) ]

Gene ID: 9183, updated on 3-Apr-2024

Summary

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Official Symbol
ZW10provided by HGNC
Official Full Name
zw10 kinetochore proteinprovided by HGNC
Primary source
HGNC:HGNC:13194
See related
Ensembl:ENSG00000086827 MIM:603954; AllianceGenome:HGNC:13194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZW10; KNTC1AP
Summary
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q23.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (113733187..113773692, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (113743514..113784012, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113603909..113644414, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113560062-113560563 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:113560791-113561990 Neighboring gene transmembrane serine protease 5 Neighboring gene mitochondrial translational release factor 1 like pseudogene 1 Neighboring gene ribosomal protein S29 pseudogene 19 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5542 Neighboring gene claudin 25 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Li Y, et al. Cell Res, 2007 Aug. PMID 17680027
  2. Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function. Varma D, et al. J Cell Biol, 2006 Feb 27. PMID 16505164, Free PMC Article
  3. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain. Vos LJ, et al. Biochem J, 2011 May 15. PMID 21345172
  4. N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function. Inoue M, et al. Genes Cells, 2008 Aug. PMID 18782227
  5. Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. Famulski JK, et al. J Cell Biol, 2008 Feb 11. PMID 18268100, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RZZ complex was purified to homogeneity and subjected to systemic crystallization.
    Title: Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.
  2. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
    Title: hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
  3. Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
    Title: Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.
  4. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner.
    Title: N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.
  5. Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase activity.
    Title: Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores.
  6. Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
    Title: Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
  7. RNAi-mediated depletion of ZW10 markedly-reduced congression efficiency.
    Title: Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.
  8. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG.
    Title: Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
  9. show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells
    Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.
  10. targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
    Title: Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables centromeric DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Dsl1/NZR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Dsl1/NZR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RZZ complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore microtubule NAS
Non-traceable Author Statement
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centromere/kinetochore protein zw10 homolog
Names
ZW10 homolog, centromere/kinetochore protein
ZW10, kinetochore associated, homolog
zeste white 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004724.4 → NP_004715.1  centromere/kinetochore protein zw10 homolog

    See identical proteins and their annotated locations for NP_004715.1

    Status: REVIEWED

    Source sequence(s)
    BC128264, BM833775, BQ773926, DB506745, U54996
    Consensus CDS
    CCDS8363.1
    UniProtKB/Swiss-Prot
    A1A528, O43264
    UniProtKB/TrEMBL
    B2R7C2
    Related
    ENSP00000200135.3, ENST00000200135.8
    Conserved Domains (2) summary
    pfam06248
    Location:9 → 621
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:598 → 768
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    113733187..113773692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018558.3 → XP_016874047.1  centromere/kinetochore protein zw10 homolog isoform X1

    UniProtKB/TrEMBL
    B2R7C2
    Conserved Domains (2) summary
    pfam06248
    Location:9 → 557
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:534 → 704
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    113743514..113784012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370507.1 → XP_054226482.1  centromere/kinetochore protein zw10 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43264.3 GenPept UniProtKB/Swiss-Prot:O43264

Gene LinkOut

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