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VP35 polymerase complex protein [ Orthomarburgvirus marburgense ]

Gene ID: 920948, updated on 18-Aug-2023

Summary

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Gene symbol
VP35
Gene description
polymerase complex protein
Locus tag
MARV_gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Orthomarburgvirus marburgense (isolate: Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Orthomarburgvirus
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Genomic context

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Sequence:
NC_001608.3 (2854..4410)

NC_001608.3Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene matrix protein Neighboring gene glycoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001608.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses. Albariño CG, et al. Virology, 2015 Feb. PMID 25531184, Free PMC Article
  2. Exploring the mechanism how Marburg virus VP35 recognizes and binds dsRNA by molecular dynamics simulations and free energy calculations. Xue Q, et al. Biopolymers, 2014 Aug. PMID 24459115
  3. Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Ramanan P, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23185024, Free PMC Article
  4. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. Bale S, et al. PLoS Pathog, 2012 Sep. PMID 23028316, Free PMC Article
  5. Mapping of two dominant sites of VP35 of Marburg virus. Sorokin AV, et al. Viral Immunol, 2002. PMID 12479397

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of the Marburg virus NP core/NP binding peptide of VP35 complex at a resolution of 2.6 A revealed that NP binding peptide of VP35 binds to the C-terminal region of the NP core via electrostatic and nonpolar interactions.
    Title: Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus.
  2. Moreover, the VP35 peptide-chaperoned NPcore remains in a monomeric state and completely loses its affinity for single-stranded RNA (ssRNA).
    Title: Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus.
  3. In cell culture, Marburg virus infection results in a greater upregulation of IFN responses as compared to Ebolavirus infection, which correlates with differences in the efficiencies by which EBOV and MARV VP35s antagonize RIG-I signaling.
    Title: Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.
  4. Three important residues Arg271, Arg294, and Lys298 which makes the largest contribution for binding in VP35 lose their binding affinity significantly in mutants.
    Title: Exploring the mechanism how Marburg virus VP35 recognizes and binds dsRNA by molecular dynamics simulations and free energy calculations.
  5. Specific mutations in the IFN inhibitory domain (IID) of MARV VP35 that abrogate host immune responses.
    Title: Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses.
  6. studies suggest VP35 can both coat the backbone and cap the ends of dsRNA, and that for MARV, coating of the dsRNA backbone may be an essential mechanism by which dsRNA is masked from backbone-sensing immune surveillance molecules
    Title: Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.
  7. The crystal structure of MARV VP35 IID in complex with 18-bp dsRNA reveals that despite the similar protein fold as EBOV VP35 IID, MARV VP35 IID interacts with the dsRNA backbone and not with blunt ends.
    Title: Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
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General gene information

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Homology

General protein information

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Preferred Names
polymerase complex protein
YP_001531154.1
  • polymerase cofactor; type I interferon antagonist

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001608.3 Reference assembly

    Range
    2854..4410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001531154.1 polymerase complex protein [Orthomarburgvirus marburgense]

    See identical proteins and their annotated locations for YP_001531154.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O36425, P35259, Q38L44, Q6T6U2, Q6UY68
    UniProtKB/TrEMBL
    A0A6C0WDP3
    Conserved Domains (1) summary
    pfam02097
    Location:1 → 329
    Filo_VP35; Filoviridae VP35
Protein Accession Links
GenPept Link UniProtKB Link
ABA87125.1

Gene LinkOut

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Molecular Biology Databases
Research Materials