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GLP2R glucagon like peptide 2 receptor [ Homo sapiens (human) ]

Gene ID: 9340, updated on 3-Apr-2024

Summary

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Official Symbol
GLP2Rprovided by HGNC
Official Full Name
glucagon like peptide 2 receptorprovided by HGNC
Primary source
HGNC:HGNC:4325
See related
Ensembl:ENSG00000065325 MIM:603659; AllianceGenome:HGNC:4325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
Expression
Biased expression in gall bladder (RPKM 4.7), small intestine (RPKM 2.6) and 8 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (9825924..9892099)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (9733669..9799834)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9729241..9795416)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:9680825-9681382 Neighboring gene DHRS7C intron CAGE-defined high expression enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47652 Neighboring gene dehydrogenase/reductase 7C Neighboring gene uncharacterized LOC124903925 Neighboring gene GSG1 like 2 Neighboring gene nucleophosmin 1 pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9802365-9802866 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9828374-9829300 Neighboring gene recoverin Neighboring gene growth arrest specific 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:9862137-9862330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9884467-9884968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929360-9929865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929866-9930370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9937053-9937552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9936551-9937052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11728 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9964299-9964800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9971697-9972196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10010547-10011088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10021115-10021644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10020585-10021114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10022175-10022702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10022877-10023835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10030567-10031284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074140-10074966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074967-10075792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10076620-10077445 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:10083873-10084415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide. Jamshidi Kandjani O, et al. Int J Biol Macromol, 2021 Aug 1. PMID 34174312
  2. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Sun W, et al. Cell Res, 2020 Dec. PMID 33239759, Free PMC Article
  3. Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status. Li F, et al. Int J Obes (Lond), 2017 Aug. PMID 28337026
  4. The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis. Guan X. Am J Physiol Regul Integr Comp Physiol, 2014 Sep 15. PMID 24990862, Free PMC Article
  5. GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. Körner M, et al. Mol Cell Endocrinol, 2012 Nov 25. PMID 22951144

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
    Title: A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
  2. Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide.
    Title: Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide.
  3. Epicardial, pericardial fat and glucagon-like peptide-1 and -2 receptors expression in stable patients with multivessel coronary artery disease: an association with the renin-angiotensin-aldosterone system.
    Title: Epicardial, pericardial fat and glucagon-like peptide-1 and -2 receptors expression in stable patients with multivessel coronary artery disease: an association with the renin-angiotensin-aldosterone system.
  4. Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
    Title: Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
  5. This is the first evidence of abnormal gene expression of GLP-1R and GLP-2R in postmortem brain of individuals with Mood Disorder.
    Title: The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders.
  6. GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCzeta expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.
    Title: Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status.
  7. GLP-2 augmented BRIN BD11 beta-cell proliferation, but was less efficacious in 1.1B4 cells. These data highlight the involvement of GLP-2 receptor signalling in the adaptations to pancreatic islet cell stress.
    Title: Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival.
  8. This is the first time that human Epicardial adipose tissue is found to express both GLP-1R and GLP-2R genes.
    Title: Human Epicardial Fat Expresses Glucagon-Like Peptide 1 and 2 Receptors Genes.
  9. Report gastrointestinal GLP-2 receptor and limited utility of GLP-2 in the management of inflammatory intestinal disorders.
    Title: Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
  10. GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease.
    Title: GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables glucagon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucagon stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
glucagon-like peptide 2 receptor
Names
GLP-2 receptor
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004246.3 → NP_004237.1  glucagon-like peptide 2 receptor

    See identical proteins and their annotated locations for NP_004237.1

    Status: REVIEWED

    Source sequence(s)
    AC026591, AK314269, BC096262
    Consensus CDS
    CCDS11150.1
    UniProtKB/Swiss-Prot
    O95838, Q4VAT3
    UniProtKB/TrEMBL
    A0A384MTS7, B2RAN4
    Related
    ENSP00000262441.5, ENST00000262441.10
    Conserved Domains (2) summary
    pfam02793
    Location:93 → 162
    HRM; Hormone receptor domain
    cd15266
    Location:175 → 453
    7tmB1_GLP2R; glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    9825924..9892099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524077.4 → XP_011522379.1  glucagon-like peptide 2 receptor isoform X1

    UniProtKB/TrEMBL
    B2RAN4
    Conserved Domains (2) summary
    pfam00002
    Location:200 → 457
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:93 → 187
    HRM; Hormone receptor domain

  2. XM_017025339.2 → XP_016880828.1  glucagon-like peptide 2 receptor isoform X2

    UniProtKB/TrEMBL
    B2RAN4

  3. XM_017025340.2 → XP_016880829.1  glucagon-like peptide 2 receptor isoform X3

    UniProtKB/TrEMBL
    B2RAN4

  4. XM_017025341.2 → XP_016880830.1  glucagon-like peptide 2 receptor isoform X4

    UniProtKB/TrEMBL
    I3L0P5
    Related
    ENSP00000458242.1, ENST00000574745.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    9733669..9799834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317814.1 → XP_054173789.1  glucagon-like peptide 2 receptor isoform X1

  2. XM_054317815.1 → XP_054173790.1  glucagon-like peptide 2 receptor isoform X2

  3. XM_054317816.1 → XP_054173791.1  glucagon-like peptide 2 receptor isoform X3

  4. XM_054317817.1 → XP_054173792.1  glucagon-like peptide 2 receptor isoform X4

  5. XM_054317818.1 → XP_054173793.1  glucagon-like peptide 2 receptor isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95838.1 GenPept UniProtKB/Swiss-Prot:O95838

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