Clec2i C-type lectin domain family 2, member i [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec2iprovided by MGI
Official Full Name: C-type lectin domain family 2, member iprovided by MGI
Primary source: MGI:MGI:2136650
See related: Ensembl:ENSMUSG00000030365 AllianceGenome:MGI:2136650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clrg; Dcl1; Clr-g; LCL-1; OCILrP2
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; regulation of actin filament polymerization; and regulation of interleukin-2 production. Located in external side of plasma membrane. Is expressed in large intestine; lymph node; testis; and thymus. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 2.0), spleen adult (RPKM 2.0) and 9 other tissues See more
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Genomic context

Location:: 6 F3; 6 63.1 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128864550..128875131)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128887587..128898168)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage.
Title: Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage.
Data show OCILRP2 binding to DAP12 resulting in Raf-MAP kinase pathways activation and T-cell activation.
Title: The C-type lectin OCILRP2 costimulates EL4 T cell activation via the DAP12-Raf-MAP kinase pathway.
OCILRP2 is a regulator of dendritic cells maturation and differentiation following TLR4 activation.
Title: OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells.
The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential.
Title: Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties.
May facilitate lipid rafts and immunological synapse formation during T cell interaction with antigen presenting cells.
Title: Silencing OCILRP2 leads to intrinsic defects in T cells in response to antigenic stimulation.
studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo
Title: C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production.
Identification of a novel family of genes, named Clr, encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Title: Cloning of Clr, a new family of lectin-like genes localized between mouse Nkrp1a and Cd69.
mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr are intertwined in a genetically conserved NKC region.
Title: Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables natural killer cell lectin-like receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables natural killer cell lectin-like receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane raft assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of osteoclast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of immunological synapse formation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 2 member I

Names: C-type lectin-related protein DCL1; C-type lectin-related protein G; lymphoid-derived C-type lectin-1; ocil-related protein 2; osteoclast inhibitory lectin related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289706.1 → NP_001276635.1 C-type lectin domain family 2 member I isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA175075, AC102693, AK041724, AY256574, BE686253

Consensus CDS

CCDS80618.1

UniProtKB/TrEMBL

E0CX52, G4WMY3

Related

ENSMUSP00000124910.2, ENSMUST00000162666.4

Conserved Domains (1) summary

cd03593
Location:121 → 233

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001289707.1 → NP_001276636.1 C-type lectin domain family 2 member I isoform 3

See identical proteins and their annotated locations for NP_001276636.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AA175075, AC102693, AK041724, AY137344, BE686253

Consensus CDS

CCDS71844.1

UniProtKB/TrEMBL

B7ZP15, G4WMY3

Related

ENSMUSP00000123804.2, ENSMUST00000159866.8

Conserved Domains (1) summary

cd03593
Location:96 → 208

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001289708.1 → NP_001276637.1 C-type lectin domain family 2 member I isoform 4 precursor

See identical proteins and their annotated locations for NP_001276637.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.

Source sequence(s)

AA175075, AC102693, AK041724, AY256576, BE686253

Consensus CDS

CCDS85166.1

UniProtKB/Swiss-Prot

Q9WVF9

Related

ENSMUSP00000145115.2, ENSMUST00000160867.3

Conserved Domains (1) summary

cd03593
Location:31 → 143

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001381961.1 → NP_001368890.1 C-type lectin domain family 2 member I isoform 5

Status: VALIDATED

Source sequence(s)

AC102693

UniProtKB/TrEMBL

G4WMY3

Conserved Domains (1) summary

PHA02642
Location:69 → 229

PHA02642; C-type lectin-like protein; Provisional
NM_020257.2 → NP_064653.1 C-type lectin domain family 2 member I isoform 2

See identical proteins and their annotated locations for NP_064653.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA175075, AC102693, AK041724, AY137345, BE686253

Consensus CDS

CCDS51920.1

UniProtKB/Swiss-Prot

Q1AFZ2, Q7TSP6, Q7TSP7, Q8BFR3, Q924B1, Q9WVF9

UniProtKB/TrEMBL

B2RTA4, G4WMY3

Related

ENSMUSP00000032519.6, ENSMUST00000032519.12

Conserved Domains (1) summary

cd03593
Location:92 → 204

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)