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Gpnmb glycoprotein (transmembrane) nmb [ Mus musculus (house mouse) ]

Gene ID: 93695, updated on 23-Jun-2021

Summary

Official Symbol
Gpnmbprovided by MGI
Official Full Name
glycoprotein (transmembrane) nmbprovided by MGI
Primary source
MGI:MGI:1934765
See related
Ensembl:ENSMUSG00000029816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dch; ipd; DC-H; Dchil; DC-HIL
Expression
Biased expression in bladder adult (RPKM 24.4), genital fat pad adult (RPKM 18.0) and 8 other tissues See more
Orthologs
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Genomic context

See Gpnmb in Genome Data Viewer
Location:
6 B2.3; 6 23.82 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49013449..49044413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49036518..49058182)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (48986517..49008181)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930563H07 gene Neighboring gene amiloride binding protein 1 (amine oxidase, copper-containing) pseudogene Neighboring gene predicted gene, 52881 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene predicted gene 7890

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tissue remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane glycoprotein NMB
Names
dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand
dendritic cell-associated transmembrane protein
iris pigment dispersion
osteoactivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053110.4NP_444340.3  transmembrane glycoprotein NMB precursor

    See identical proteins and their annotated locations for NP_444340.3

    Status: VALIDATED

    Source sequence(s)
    AC153620, AK171465, AK171517, BY205729
    Consensus CDS
    CCDS20122.1
    UniProtKB/Swiss-Prot
    Q99P91
    Related
    ENSMUSP00000031840.8, ENSMUST00000031840.10
    Conserved Domains (1) summary
    cd00146
    Location:256316
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49013449..49044413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152412.1XP_036008305.1  transmembrane glycoprotein NMB isoform X1

    Related
    ENSMUSP00000145376.2, ENSMUST00000204260.2
    Conserved Domains (1) summary
    cd00146
    Location:256316
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...
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